Alligator Bioscience Ab

Aptevo Reserch and Development LLC

Danielle Van Citters

Christina Furebring

Peter Ellmark

Laura Von Schantz

Sara Fritzell

Laura Varas

Lynda Misher

David Bienvenue

Gabriela Hernandez-Hoyos

Anna Sall

The present disclosure relates to protein molecules that specifically bind to 5T4 and/or 4-1BB. The molecules may have at least one humanized 5T4-binding or 4-1BB-binding domain. Such molecules are useful for the treatment of cancer. The protein molecule binding to 5T4 or 4-1BB may have a second binding domain that binds to another target. The molecules may bind both 5T4-expressing cells and a cell-surface molecule expressed by an effector cell to enhance effector cell activation, proliferation, survival and/or effector-cell mediated cytotoxicity. The disclosure also provides pharmaceutical compositions comprising the 5T4-binding or 4-1BB-binding polypeptide or protein molecules, nucleic acid molecules encoding these polypeptides and methods of making and using these molecules.

Antigen binding proteins binding to 5T4 and 4-1BB and related compositions and methods

Growing community of inventors

Seattle, WA, United States of America

Danielle Van Citters