Amgen Inc.

Danielle Feldman

Ian B Hanson

Kevin Lee Bokelman

Lawton Laurence

Daniel Shawn Codd

Rajan Ramaswamy

Matthew J Clemente

Scott Beaver

Antonio Ubach

Sheldon B Moberg

Scott Robert Gibson

Paul F Bente, Iv

Margaux Frances Boyaval

John Christian Love

Sean M O'connor

Mark A Destefano

Basel Hasan Taha

Ian P Dardani

The present invention provides devices and methods for establishing aseptic connections between two or more components or subassemblies. The devices may be used in medical devices such as drug delivery pumps (). In some embodiments, a connection is made between a drug container () and a fluid pathway connection assembly (). The fluid pathway connection assembly may include a connection hub (), a piercing member (), and a piercing member retainer (). The assembly may further include a first film () covering a cavity (A,A,A), thereby maintaining the aseptic condition of the cavity. The drug container may hold a fluid drug and include a pierceable seal (). A second film () may cover a recess () formed by the seal and thereby maintain the aseptic condition of the interior of the chamber. The piercing member may be caused to pierce the first and second film and the pierceable seal to open a fluid pathway for delivery of the fluid drug through the fluid pathway connection assembly.

Device and method for making aseptic connections

Disclosed herein is a wearable drug delivery device including a container filled at least partially with a drug including at least one of a PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9) specific antibody, a granulocyte colony-stimulating factor (G-CSF), a sclerostin antibody, or a calcitonin gene-related peptide (CGRP) antibody. The wearable drug delivery device may include a needle and an insertion mechanism configured to insert the needle into a patient. A fluid pathway connector may define a sterile fluid flowpath between the container and the insertion mechanism. Optionally, a cannula initially disposed about the needle may be included. The cannula may be retained in the patient at an injection site created by the needle after the needle is withdrawn from the patient. Methods of assembly and operation are also provided.

Drug delivery device, method of manufacture, and method of use

Disclosed herein is a wearable drug delivery device including a container filled at least partially with a drug including at least one of a PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9) specific antibody, a granulocyte colony-stimulating factor CSF), a sclerostin antibody, or a calcitonin gene-related peptide (CGRP) antibody. The wearable drug delivery device includes a needle and an insertion mechanism configured to insert the needle into a patient. A fluid pathway connector defines a sterile fluid flowpath between the container and the insertion mechanism. A cannula initially disposed about the needle is included.

Growing community of inventors

Philadelphia, PA, United States of America

Danielle Feldman