Syracuse University

Danieli C Rodrigues

Jeremy L Gilbert

Julie M Hasenwinkel

Rebecca A Bader

The present invention relates to bone cements and, more particularly, to acrylic-based orthopedic bone cements, their use in spinal applications, and methods for making the same. An embodiment of the present invention provides multi-solution bone cements which include cross-linked PMMA beads, a linear polymer, and a monomer with various polymer to monomer ratios, and polymer bead to linear polymer ratios. The bone cement can include a polymer to monomer (P:M) ratio of between about 1:1 and 1.4:1, and can also include a polymer bead to linear polymer ratio of between about 1:1 and 2:1. Another embodiment of the present invention provides the use of a radiopacifier in the bone cement composition, such as ZrO, in increasing concentrations.

Multi-solution bone cements and methods of making the same

The present invention relates to bone cements and, more particularly, to acrylic-based orthopedic bone cements, their use in spinal applications, and methods for making the same. An embodiment of the present invention provides a method of grafting PMMA brushes on cross-linked PMMA nanospheres comprising at least one of the following steps: performing a hydrolysis reaction of surface methyl ester groups of said cross-linked PMMA nanospheres to form surface carboxylic acid groups of said cross-linked PMMA nanospheres; forming a 2-aminoethyl acrylate compound; coupling said surface carboxylic acid groups of said cross-linked PMMA nanospheres with said 2-aminoethyl acrylate compound to form a coupled compound with an initiating site; and grafting said PMMA brushes onto said initiating site. Another embodiment of the present invention includes an orthopedic bone cement including cross-linked PMMA nanospheres comprising PMMA brushes prepared by this method, and a monomer, wherein polymer to monomer ratio is between about 1:1 and 1.3:1.

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Syracuse, NY, United States of America

Danieli C Rodrigues