Fin-ceramica Faenza S.p.a.

Fidia Advanced Biopolymers S.r.l.

Consiglio Nazionale Delle Ricerche

Universidade De Santiago De Compostela

Anika Therapeutics S.r.l.

Daniele Pressato

Anna Tampieri

Elena Landi

Lanfranco Callegaro

Alessandra Pavesio

Sergio Di Fede

Claudio De Luca

Andrea Pastorello

Simone Sprio

Monica Sandri

Maurilio Marcacci

José Rivas Rey

Roberta Martinetti

Manuel Banobre López

Giancarlo Celotti

Mauro Fiorini

Laura Dolcini

Alberto Rivarossa

Manuel Banobre Lopez

The present invention relates to hydroxyapatite doped with Feions and Feions which partially substitute the calcium ions in the crystal lattice. The hydroxyapatite is characterized by an intrinsic magnetism of 0.05 to 8 emu/g, measured by applying a magnetic field of 34 Oe, due to the presence of magnetic nano-domains in the crystal lattice of HA, given the limited amount of magnetic secondary phases present, less than about 3% by volume. The intrinsically magnetic hydroxyapatite can be loaded with biological substances selected in the group consisting of proteins, genes, stem cells, growth factors, vascularization factors, active substances and drugs, under the control of an external magnetic field, as a carrier and release agent for biological substances or drugs, as a contrast agent in diagnostics or for bone or osteocartilage regeneration.

Intrinsically magnetic hydroxyapatite

The present invention relates to a hydroxyapatite multi-substituted with, physiologically compatible ion species and to its biohybrid composite with a natural and/or synthetic polymer, which are useful in the preparation of a biomimetic bone substitute for treating bone tissue defects. Furthermore, the present invention relates to a method for their preparation and uses.

Plurisubstituted hydroxyapatite and the composite thereof with a natural and/or synthetic polymer, their preparation and uses thereof

The present invention relates to a multilayer structure () including a first upper layer () consisting of an organic matrix including collagen and at least a lower layer () consisting of a composite matrix including hydroxylapatite and collagen. Furthermore, the present invention relates to a cartilaginous substitute including said multilayer structure () as well as an osteochondral substitute including said multilayer structure (). Finally, the present invention relates to the use of said multilayer structure () for the preparation of said cartilaginous substitute and said osteochondral substitute for the treatment of cartilaginous defects and osteochondral defects or for the neo-formation of a cartilaginous tissue and/or a subchondral bone tissue.

Cartilaginous and osteochondral substitute comprising multilayer structure and use thereof

A method for perfusing a biocompatible material graft with a perfusion liquid includes the steps of: introducing the graft () in a perfusion chamber (), arranging a transfer chamber () partly filled with the perfusion liquid (), coupling in a tight manner the perfusion chamber () and the transfer chamber () for establishing a fluid communication between them, lowering the pressure in the transfer chamber () for transferring therein part of the air existing in the perfusion chamber (), increasing the pressure within the transfer chamber () for injecting in the perfusion chamber () the perfusion liquid () existing in the transfer chamber (). A perfusion kit includes a perfusion chamber () apt to contain a graft () to be perfused with a liquid () and a transfer chamber () apt to contain a liquid () to be perfused, the perfusion chamber () being connectable in a tight manner with the transfer chamber () for allowing a fluid exchange between the two chambers () and inhibiting a fluid exchange between the two chambers () and the external environment.

Method for perfusing a biocompatible material graft with a liquid and perfusion kit

The object of the present invention is a process for obtaining a bone substitute of given chemical and physical characteristics and entirely similar to those of the mineral portion of natural bone tissue. The process substitutes Ca ions with Mg ions in a porous matrix; the process comprises a phase of contacting the matrix with a saline aqueous solution containing an effective quantity of Mg ions at a pressure greater than or equal to 1 bar.

Process for the preparation of a biomimetic bone substitute and its uses

A composite material comprising: (i) hyaluronic acid and/or hyaluronic acid derivatives, (ii) demineralised bone and/or biocompatible partially or totally demineralised bone tissue matrix and/or biocompatible and bioresorbable ceramic materials. This material preferably associated with at least one layer comprising a hyaluronic acid derivative may be used in the preparation of bone substitutes or grafts for the regeneration or formation of bone tissue in surgery.

Composite structures containing hyaluronic acid the derivatives thereof as new bone substitutes and grafts

New biomaterials essentially constituted by esterified derivatives of hyaluronic acid or by cross-linked derivatives of hyaluronic acid for use in the surgical sector, particularly for use in the prevention of post-surgical adhesions.

Biomaterials for preventing post-surgical adhesions comprised of hyaluronic acid derivatives

The present invention describes the use of polysaccharide derivatives for the preparation of biocompatible and biodegradable biomaterials with absorbent properties for body fluids and physical hemostatic activity, to be used in both venous and arterial vascular anastomoses to create a physical hemostatic barrier and to prevent scar tissue formation and formation of post-surgical adherence of the vessels to the surrounding tissues.

Use of hyaluronic acid derivatives in the preparation of biomaterials with a physical haemostatic and plugging activity

New biomaterials essentially constituted by esterified derivatives of hyaluronic acid or by cross-linked derivatives of hyaluronic acid for use in the surgical sector, particularly for use in the prevention of post-surgical adhesion.

Growing community of inventors

Montegrotto Terme, Italy

Daniele Pressato