L. Molteni & C. Dei Fratelli Alitti—società Di Esercizio S.p.a.

Molteni Therapeutics S.r.l.

L. Molteni & C. Dei Fratelli Alitti

L. Molteni E C. Dei Fratelli Alitti Societa Di Esercizio S.p.a.

L. Molteni & C. Dei Fratelli Alitti Societa' Di Esercizio Societa' Per Azioni

Daniele Nistri

Gabrio Roncucci

Donata Dei

Giacomo Chiti

Lia Fantetti

Valentina Paschetta

Annalisa Cocchi

Francesca Giuntini

Giulio Jori

Maria Paola De Filippis

Salvatore Demartis

Moira Municchi

Aldo Hendrikus Velders

Yann Raoul

There is described a phthalocyanine derivative of formula (I) consisting of 4 isomers wherein the relative isomer B content is less than or equal to 1% by weight. 

Phthalocyanine derivative consisting of a mixture of 4 isomers

Meso-substituted porphyrins of general formula (I) suitable for the use as photosensitizing agents, in particular in photodynamic therapy, are herein described.

Meso-substituted porphyrins

A process is described for preparing chlorides of phthalocyanine derivatives comprising at least a quaternary ammonium group, products useful as photosensitizing agents in photodynamic therapy.

Process for preparing chlorides of phthalocyanine derivatives comprising at least a quaternary ammonium group

Meso-substituted porphyrins of general formula (I) suitable for the use as photosensitizing agents, in particular in photodynamic therapy, are herein described. 

The present invention relates to metal-phthalocyanines bearing at least a group containing boron isotopesB orB, covalently bound to the axial positions of metal-phthalocyanine nucleus; moreover it refers to the process for their preparation, the pharmaceutical compositions comprising them and their use for the treatment of neoplastic and dysplastic pathologies in PDT and/or BNCT.

Boronated metal-phthalocyanines, process for their preparation, pharmaceutical compositions comprising them and use thereof

Phthalocyanine analogues having an active group able to link the phthalocyanine t carriers molecules and phthalocyanine to carriers molecules and phthalocyanine analogues as phthalocyanine-carrier conjugates showing enhanced photodynamic properties, red shifted absorption characteristic, all useful for photodynamic therapy, are described. Photosensitizers themselves or the photosensitizers-carriers conjugates are useful compounds either for treatment of various infectious diseases, the in vivo eradication of micro-organisms as well as diseases characterized by cellular hyperproliferation, in particular tumours psoriasis, actinic keratosis, atheromas, endoarterial hyperplasia and prostate hyperplasia. The above compounds can be also useful for blood and blood derivatives sterilization and in vivo/vitro diagnostics.

Metal substituted non-centrosimmetrical phthalocyanine analogues, their preparation and use in photodynamic therapy and in vivo diagnostic

Growing community of inventors

Prato, Italy

Daniele Nistri