Novartis Vaccines & Diagnostics, Gmbh

Chiron Corporation

Daniela Tornese Buonamassa

Cesira Galeotti

Giuliano Bensi

Catherine Greer

Roberto Petracca

Mosaic VLPs of viral capsid proteins from different virus types are described, as are methods of making the same. Specifically, a diploid yeast strain that coexpresses the L1 and L2 capsid proteins of both HPV-6 and HPV-16 as mosaic VLPs is described. The mosaic VLPs induced the production of conformational antibodies against both L1 proteins upon administration to mice.

Method for producing yeast expressed HPV types 6 and 16 capsid proteins

Mosaic VLPs of viral capsid proteins from different virus types are described, as are methods of making the same. Specifically, a diploid yeast strain that coexpresses the L1 and L2 capsid proteins of both HPV-6 and HPV-16 as mosaic VLPs is described. The mosaic VLPs induced the production conformational antibodies against both L1 proteins upon administration to mice.

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Siena, Italy

Daniela Tornese Buonamassa