Univerzita Palackeho V Olomouci

Institute of Experimental Botany

Ustav Experimentalni Botaniky Av Cr, V.v.i.

Daniela Moravcová

Miroslav Strnad

Vladimir Krystof

Libor Havlicek

René Lenobel

The invention relates to 3-, 5-, 7-trisubstituted pyrazolo[4,3-d]pyrimidines represented by the general formula I and pharmaceutically acceptable salts thereof, whereinR3 is an optionally substituted alkyl, cycloalkyl, cycloheteroalkyl, cycloalkyl alkyl, aryl or alkylaryl group;R5 is halogen, &#x2014;NHNH, &#x2014;NHOH, NHCONH, guanylo (NH&#x2014;C(NH)NH) an optionally substituted C-Calkyl, alkenyl, alkynyl, C-Ccycloalkyl, R(C-Ccycloalkyl), heterocyclyl, heteroalkyl, aryl, heteroaryl, arylalkylene, arylalkenylene, arylalkynylene, cycloheteroalkyl, cycloheteroalkyl alkyl, heteroarylalkylene, heteroarylalkenylene, heteroarylalkynylene group, the group &#x2014;C(O)&#x2014;R, &#x2014;C(O)NRR, &#x2014;SOR, or &#x2014;NHC(O)R, wherein Rand Rare an optionally substituted C-Calkyl, alkenyl, or alkynyl group, R, R, and Rare independently selected from the group consisting of H, optionally substituted C-Calkyl, alkenyl, or alkynyl group, and Ris a hydroxy, amino, alkoxy, alkylamino, optionally substituted C-Calkyl, alkenyl or alkynyl group; or the group &#x2014;X&#x2014;R, wherein X is &#x2014;NH&#x2014;, &#x2014;O&#x2014;, &#x2014;S&#x2014; or &#x2014;N(alkyl)- and R' is hydrogen, an optionally substituted C-Calkyl, alkenyl, alkynyl, C-Ccycloalkyl, Rf(C-Ccycloalkyl), aryl, heterocyclyl, hetero C-Calkyl, arylalkylene, arylalkenylene, arylalkynylene, heteroaryl, cycloheteroalkyl, cycloheteroalkyl alkyl, or heteroarylalkylene, heteroarylalkenylene, heteroarylalkynylene group, the group &#x2014;C(O)&#x2014;R, &#x2014;C(O)NRR, &#x2014;SOR, or &#x2014;NHC(O)R, wherein R, R, R, R, Rand Rhave the above meaning, andR7 is halogen, &#x2014;NHNH, NHOH, NHCONH, guanylo (NH&#x2014;C(NH)NH) or the group &#x2014;X&#x2014;R, wherein X has the above meaning and the meaning of Ris as defined for R.

Growing community of inventors

Horazd'ovice, Czechia

Daniela Moravcová