Farmitalia Carlo Erba S.r.l.

Nerviano Medical Sciences S.r.l.

Pharmacia & Upjohn S.p.a.

Sclavo Spa

Daniela Faiardi

Antonino Suarato

Michele Caruso

Alberto Bargiotti

Tiziano Bandiera

Jacqueline Lansen

Italo Beria

Francesco Angelucci

Gabriella Traquandi

Nicola Mongelli

Claudio Fuganti

Francesco Casuscelli

Matteo Salsa

Maria Grandi

Antonella Ermoli

Claudia Piutti

Eva Baldaro

Stefania Stefanelli

Ameriga Lazzarini

The present disclosure is directed to a compound of formula (I) wherein L is null or a conditionally-cleavable moiety; W is null or a self-immolative system, comprising one or more self-immolative groups; Z is null or a peptidic, non peptidic or hybrid &#x2014;peptidic and non peptidic&#x2014;linker; RM is null or a reactive moiety that can be attached to one or more of L, W or Z groups, or RM is attached to oxygen when L, W and Z are all null; provided that at least one of L, W, Z and RM is not null; or a pharmaceutically acceptable salt thereof.

Functionalized 9-bromo-camptothecin derivatives

The present invention relates to substituted pyrazolo[4,3-h]quinazoline compounds which modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity, in particular PIM kinases. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing such these compounds or the pharmaceutical compositions containing them.

Substituted pyrazolo-quinazoline derivatives as kinase inhibitors

The present invention provides imino aza-anthracyclinones and a method of treating amyloidoses using the same.

Anthracycline derivatives

Aza-anthracyclinone derivatives

2-acyloxy-4-morpholinyl anthracyclines

An anthracycline glycoside of general formula 1: ##STR1## wherein R.sub.1 is hydrogen or methoxy group; R.sub.2 is hydrogen or hydroxy group, A and B both represent hydrogen or one of A and B is hydrogen and the other is hydroxy or a group of formula --OSO.sub.2 R.sub.5 in which R.sub.5 is C1-C4 alkyl or aryl optionally substituted by C1-C4 alkyl, nitro, amino, methoxy or halogen; R.sub.3 is a hydrogen atom or a group of formula 2 and R.sub.4 is a group of formula 2

Mono and bis alkylamino-anthracyclines

Anthracycline glycosides having the general formula 1 and 2: ##STR1## wherein R.sub.1 is selected from the group consisting of hydrogen, fluorine, hydroxy or amino; R.sub.2 and R.sub.3 represent hydroxy or one of R.sub.2 and R.sub.3 is a hydrogen atom, a nitro or an amino group and the other of R.sub.2 and R.sub.3 is a HYDROXY group, exhibit activity against LoVo and LoVo/Dx in vitro.

New 4'-epi-4'-amino anthracyclines

Morpholinyl derivatives of doxorubicin having the general formula A: ##STR1## in which X represents a linear or branched C.sub.2 -C.sub.6 alkyl group or a benzyl group --CH.sub.2 C.sub.6 H.sub.5 and which have (S) or (R) configuration at carbon atom C-2' of the morpholino ring, are antitumor agents.

Morpholinyl derivatives of doxorubicin and process for their preparation

The present invention relates to a new method of protection of the carboxy group in the chemistry of the compounds of .beta.-lactam type. According to such a method, the carboxy group is protected by being transformed into its corresponding phenyl-acetoxy-methyl ester, which is then removed by an enzymatic route by means of penicillinacylase. In particular, if the .beta.-lactam compound also bears a phenyl-acetamidic substitutent, this latter is simultaneously hydrolysed during the same step of removal of the carboxy function protecting group.

Method of protection of the carboxy groups in the chemistry of

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Pavia, Italy

Daniela Faiardi