Bracco Imaging S.p.a.

Other

Universitá Degli Studi Di Torino

Daniela Delli Castelli

Silvio Aime

Enzo Terreno

Fulvio Uggeri

Franco Fedeli

Dario Livio Longo

Luciano Lattuada

Carlo Scolastico

Pierfrancesco Morosini

Leonardo Manzoni

Daniela Arosio

Giovanni Battista Giovenzana

Joseph Stancanello

Martina Tripepi

The present invention relates to the use of non-equivalent mobile protons belonging to NMR distinguishable steroisomers of a CEST agent in a ratiometric based CEST imaging procedure and to Lanthanide (III) complex compounds displaying at least two NMR-distinguishable steroisomers in solution useful as concentration independent CEST responsive agents.

CEST systems exhibiting a concentration independent responsiveness

The present invention relates to the use of non-equivalent mobile protons belonging to NMR distinguishable stereoisomers of a CEST agent in a ratiometric based CEST imaging procedure and to Lanthanide (III) complex compounds displaying at least two NMR-distinguishable stereoisomers in solution useful as concentration independent CEST responsive agents.

The present invention relates to a novel class of diagnostically or therapeutically effective compounds comprising novel aza-bicycloalkane based cyclic peptides, acting as a targeting moiety towards integrin receptors.

Integrin targeted synthetic ligands for diagnostic and therapeutic applications

Disclosed are CEST paramagnetic agents comprising a substrate (SH) containing mobile protons bonded to a paramagnetic chelate (SR) containing a metal selected from iron (11) (high-spin configuration), iron (111), cobalt (11), rhodium (11), copper (11), nickel (11), cerium (111), praseodymium (111), neodymium (111), dysprosium (111), erbium (111), terbium (111), holmium (111), thulium (III), ytterbium (III) and europium (111).

Adducts between magnetic resonance shift reagents and substrates containing exchangeable protons for 'cest' applications

An embodiment in the MRI-CEST field is proposed for analyzing a body-part, which includes a CEST agent providing a magnetization transfer with a bulk substrate of the body-part. A corresponding diagnostic system includes input means for providing an input map including a plurality of input elements each one for a corresponding location of the body-part; each input element is indicative of a spectrum of a magnetic response of the location, which spectrum includes the magnetic response at an agent frequency of resonance of the contrast agent (with the agent frequency that is at an agent offset of frequency from a bulk frequency of resonance of the bulk substance), and at a reference frequency at the opposite of the agent offset from the bulk frequency. The system further includes calculation means for calculating an agent value and a reference value for each one of a set of selected locations; the agent value is calculated according to the magnetic responses of the selected location in a non-punctual agent range of frequencies including the agent frequency, and the reference value is calculated according to the magnetic responses of the selected location in a non-punctual reference range of frequencies including the reference frequency (with the reference range that is symmetric to the agent range with respect to the bulk frequency). Comparison means is then provided for calculating a parametric value for each selected location; the parametric value is calculated according to a comparison between the agent value and the reference value of the selected location.

MRI-CEST diagnostic technique based on non-punctual analysis

A method is claimed based on CEST procedure for the in vivo or in vitro determination of physical or chemical parameters which includes the use of a responsive paramagnetic CEST contrast agent.

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Bibiana, Italy

Daniela Delli Castelli