Psychogenics Inc.

Hoffmann-la Roche Inc.

Carnegie Mellon University

F. Hoffmann-la Roche Ag

Daniela Brunner

Vijay Gondhalekar

Emer Leahy

David Larose

William P. Ross

Vijay M Gondhalekar

William Payne Ross

David LaRose

Sabine Kolczewski

Claus Riemer

Anja Limberg

Theodor Stoll

Eric Prinssen

Daniel W Goodman

Bavani G Shankar

Jessica Malberg

Hans Hilpert

William P Ross

The present invention is concerned with 2-oxo-2,3-dihydro-indoles of general formula (I) wherein Ar, X, X, R, R, R, m, n and the dotted line are as defined herein which compounds are useful for treating certain central nervous system disorders as described herein.

Indolin-2-one or pyrrolo-pyridin/pyrimidin-2-one derivatives

The present invention is concerned with 2-oxo-2,3-dihydro-indoles of general formula wherein is phenyl or a heteroaryl group, selected from pyridinyl, pyrimidinyl, imidazolyl, isoxazolyl or pyrazolyl; is phenyl or pyridinyl, wherein the N atom in the pyridinyl group may be on all free positions;

2-oxo-2,3-dihydro-indoles for the treatment of CNS disorders

A system and method used to assess animal behavior includes a module having sensors that collects a variety of physical and biological data from a test subject. Interpretation of the data is provided to assess the test subject's behavior, neurology, biochemistry and physiology. The module is useful in observing the effects of a drug on the test animal and providing information on the drug's signature. Another advantage is the module's portability that allows it to be used in standard laboratory cages. This portability allows the animal to be tested in its own habitat, that can reduce any erroneous data due to stressing the animal when removed to a test cage. Additionally, the module's design allows for parallel data collection and interpretation from several laboratory animals undergoing different experiments. Multi-dimensional modeling of the test subject based the system's interpretation of the data allows pattern recognition of the drug signature, and predictive drug analysis.

Method for predicting treatment classes using behavior informatics

A system and method used to assess animal behavior includes a module having sensors that collects a variety of physical and biological data from a test subject. Interpretation of the data is provided to assess the test subjects behavior, neurology, biochemistry and physiology. The module is useful in observing the effects of a drug on the test animal and providing information on the drug's signature. Another advantage is the module's portability that allows it to be used in standard laboratory cages. This portability allows the animal to be tested in its own habitat, that can reduce any erroneous data due to stressing the animal when removed to a test cage. Additionally, the module's design allows for parallel data collection and interpretation from several laboratory animals undergoing different experiments. Multi-dimensional modeling of the test subject based the system's interpretation of the data allows pattern recognition of the drug signature, and predictive drug analysis.

Method for predicting treatment classes using animal behavior informatics

A method for treating Attention Deficit/Hyperactivity Disorder (ADHD) in humans and the symptoms associated therewith, inattentiveness, and hyperactivity with impulsivity, using eltoprazine and related compounds is provided.

Treatment for attention-deficit hyperactivity disorder

Systems and methods for monitoring behavior informatics

A system and method for studying a test subject includes monitoring the test subject as it traverses through a programmable maze. The test subject may be under the influence of experimental drugs or genetic manipulation. The dynamic maze can be changed automatically or manually to test the abilities of the test subject. The dynamic maze comprises of a starting point, an ending point, and an electronically programmable floor capable of constructing various obstacles and passageways. The programmable floor may be programmed by a human user using an interface, or it may be programmed by an automated control system that programs the maze in accordance with the ability of the test subject to traverse the maze. Various devices are incorporated with the use of the maze to monitor the activities and welfare of the test subject.

Programmable electronic maze for use in the assessment of animal behavior

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Riverdale, NY, United States of America

Daniela Brunner