Zambon Group S.p.a.

Zambon Group S.a.

Daniela Botta

Gabriele Pietro Norcini

Francesco Santangelo

Franco Pellacini

Gabriele Morazzoni

Stefano Romagnano

Enrico Albini

Mauro Napoletano

Giancarlo Grancini

Domenico Ungheri

Giovanna Schioppacassi

Claudio Semeraro

Ermanno Moriggi

Julio Alvarez-Builla

Lorenzo Pradella

Jorge G Siro Herrero

Jos&eacute; Luis Garcia Navaio

Compounds of formula (I) wherein B is alkylene, amino, CONH or a bond; Cy is optionally substituted phenyl or heteroaryl; R is H, phenyl or (C )alkyl optionally substituted; R is (C )alkyl or polyfluoro(C )-alkyl; R is (C )cycloalkyl optionally containing an oxygen atom and optionally substituted; and the N&rarr;O derivatives and pharmaceutically acceptable salt thereof are PDE 4 and TNF&agr; inhibitors.

Phthalazine derivatives as phosphodiesterase 4 inhibitors

The present invention discloses an erythromycin derivative with antibiotic activity and pharmaceutically acceptable salts thereof, a process for their preparation and pharmaceutical compositions containing them as active principle.

Erythromycin derivative with antibiotic activity

Compounds of formula (I) wherein R is an alkyl, aryl or arylalkyl group wherein the aryl is phenyl naphthyl or heterocycle; R and R , the same or different, are hydrogen atoms or alkyl groups; R is an aryl or arylalkyl group wherein the aryl is as above; R is a heterocycle optionally substituted with a heterocycle or phenyl, or it is a phenyl group substituted with a heterocycle (R is not imidazole or indole); X is a bond or &mdash;OCONH or &mdash;CONH&mdash; group, processes for their preparation and pharmaceutical compositions thereof, are described. The compounds of formula (I) are endowed with a dual ACE-inhibitory and NEP-inhibitory activity and are useful in the treatment of cardiovascular disease.

Phosphonic acid derivatives with metallopeptidase inhibitory activity

Erythromycin derivatives with antibiotic activity and pharmaceutically acceptable salts thereof. A process for preparing such erythromycin derivatives and pharmaceutical compositions containing them as the active principle.

Erythromycin derivatives with antibiotic activity

3&prime;-Des-dimethylamino-9-oxyimino macrolides of formula (I) endowed with anti-inflammatory activity and their pharmaceutical use are described.

Macrolides with anti-inflammatory activity

Benzazine derivatives phosphodiesterase 4 inhibitors

Erythromycin A 9-0 oxime derivatives endowed with antibiotic activity

Phosphinic acid derivatives with metallopeptidase inhibitory activity

Compounds of formula ##STR1## wherein R, R.sub.1, R.sub.2, R.sub.3, R.sub.4 and n have the meanings reported in the description are described. The compounds of formula I are endowed with a dual ACE-inhibitory and NEP-inhibitory activity and are useful in the treatment of cardiovascular diseases.

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Como, Italy

Daniela Botta