Physical Sciences, Inc.

Other

Daniel X Hammer

R Daniel Ferguson

Nicusor V Iftimia

Chad Bigelow

Teoman E Ustun

Mircea Mujat

Cynthia A Toth

Anket H Patel

Stephen Burns

William P Roach

Gary D Noojin

A method of imaging a retina of an eye includes combining an optical path of an optical coherence tomography (OCT) imager and an optical path of a line scanning laser ophthalmoscope (LSLO) imager using a system of optics. The method also includes using a single detector to switch between an OCT mode and a LSLO mode and acquiring images of the retina while switching between the OCT mode and the LSLO mode.

Hybrid spectral domain optical coherence tomography line scanning laser ophthalmoscope

An optical apparatus includes a system of optical components capable of operating in a scanning laser ophthalmoscope (SLO) mode and an optical coherence tomography (OCT) mode. The system of optical components includes a first optical module for the SLO mode, a second optical module for the OCT mode, and a first scanning device. The first optical module for the SLO mode includes a first source adapted to provide a first imaging beam for the SLO mode and a first detection device configured to receive a first signal associated with a first image of a retina of an eye. The second optical module for the OCT mode includes a second source adapted to provide a second imaging beam for the OCT mode and a second detection device configured to receive a second signal associated with a second image of the retina. The first scanning device is configured to move the first imaging beam along the retina in the slow axis of the SLO mode to acquire the first image and (ii) to move the second imaging beam along the retina in the fast axis of the OCT mode to acquire the second image.

Multi-functional adaptive optics retinal imaging

A system provides an optical image of an object. A first module tracks a reference feature of the object. A second module includes a source for an imaging beam, a scanning device to move the imaging beam along a portion of the object and a detection device receives a signal associated with an image of the portion of the object. The first module controls the position of the imaging beam relative to the reference feature to correct for the motion of the object. A third module detects a distortion of the object and compensates for the distortion.

Stabilized retinal imaging with adaptive optics

A first optical module scans a portion of an eye with a line of light, descans reflected light from the scanned portion of the eye and confocally provides output light in a line focus configuration. A detection device detects the output light and images the portion of the eye. A second optical module detects an optical distortion and corrects the optical distortion in the line of light scanned on the portion of the eye.

Adaptive optics line scanning ophthalmoscope

An apparatus for imaging an eye includes a housing and a system of optical components disposed in the housing. The apparatus is capable of operating in a line scanning laser ophthalmoscope (LSLO) mode and an optical coherence tomography (OCT) mode. The system of optical components can include a first source to provide a first beam of light for the OCT mode and a second source to provide a second beam of light for the LSLO mode. In the OCT mode, a first optic is used that (i) scans, using a first surface of the first optic, the first beam of light along a retina of an eye in a first dimension, and (ii) descans, using the first surface, a first light returning from the eye in the first dimension to a detection system in the OCT mode. In the LSLO mode, the first optic is used where the second beam of light passes through a second surface of the first optic.

An apparatus for imaging an eye includes a housing and a system of optical components disposed in the housing. The apparatus is capable of operating in a line scanning laser opthalmoscope (LSLO) mode and an optical coherence tomography (OCT) mode. The system of optical components can include a first source to provide a first beam of light for the OCT mode and a second source to provide a second beam of light for the LSLO mode. In the OCT mode, a first optic is used that (i) scans, using a first surface of the first optic, the first beam of light along a retina of an eye in a first dimension, and (ii) descans, using the first surface, a first light returning from the eye in the first dimension to a detection system in the OCT mode. In the LSLO mode, the first optic is used where the second beam of light passes through a second surface of the first optic.

Real time, high-speed image stabilization with a retinal tracking scanning laser ophthalmoscope (TSLO) enables new approaches to established diagnostics. Large frequency range (DC to 19 kHz), wide-field (40-deg) stabilized Doppler flowmetry imaging is described for human subjects. The fundus imaging method is a quasi-confocal line-scanning laser ophthalmoscope (LSLO). The retinal tracking system uses a confocal reflectometer with a closed loop optical servo system to lock onto features in the ocular fundus and automatically re-lock after blinks. By performing a slow scan with the laser line imager, frequency-resolved retinal perfusion and vascular flow images can be obtained free of eye motion artifacts.

Monitoring blood flow in the retina using a line-scanning laser ophthalmoscope

A novel microfocusing laser surgical probe for use in intraocular surgery combines a high power laser with a gradient index (GRIN) lens to provide sufficient energy density at a focal point inside the eye to achieve laser induced breakdown and destroy fibrovascular membranes resulting from diabetes and other diseases. The gradient index lens steeply focuses the light close to its end so that the energy density of the light widely diverges beyond the focal point to reduce the potential for damage to the underlying retina. The gradient index lens also focuses the light far enough from the end of the lens to prevent damage to the lens itself. In a first embodiment, an open transmission line couples a YAG laser to a gradient index lens so that the light is still collimated when it strikes the lens. This first probe may be articulated by the use of mirrors or other optical devices. In a second embodiment, a tapered optical fiber couples a YAG laser to a gradient index lens to increase the maneuverability of the probe. An air gap separates the end of the optical fiber from the lens to better couple the light energy output from the optical fiber to the lens.

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Bedford, NH, United States of America

Daniel X Hammer