Roche Palo Alto LLC

Sri International

F. Hoffmann-la Roche Ag

Daniel Warren Parish

Michael Patrick Dillon

Ronald Charles Hawley

Alam Jahangir

Chris Allen Broka

David Scott Carter

Clara Jeou Jen Lin

Amy Geraldine Moore

Anthony P D W Ford

Clara Jeou Lin

Anthony Pdw Ford

Anthony PDW Ford

Compounds and methods for treating diseases mediated by a P2Xand/or a P2Xreceptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I): or a pharmaceutically acceptable salt, solvate or prodrug thereof,wherein D, X, Y, R, R, R, R, R, R, Rand Rare as defined herein.

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Compounds and methods for treating diseases mediated by a P2Xand/or a P2Xreceptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I): or a pharmaceutically acceptable salt, solvate or prodrug thereof,

Methods for treating respiratory and gastrointestinal diseases mediated by a P2Xand/or a P2Xreceptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I): or a pharmaceutically acceptable salt thereof,wherein D, X, Y, R, R, R, R, R, R, Rand Rare as defined herein.

Methods for treating respiratory and gastrointestinal diseases mediated by a P2Xand/or a P2Xreceptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I): or a pharmaceutically acceptable salt thereof,

Novel arylcycloalkanepolyalkylamines useful as anti-psychotic, anti-ischemia, anti-stroke, anti-dementia and anti-convulsant agents. These arylcycloalkanepolyalkylamines are selective high-affinity ligands to the sigma binding-sites containing three basic units: arylcycloalkyl group, an amine group and an intermediate chain. Their preparation and use for treatment of psychoses, ischemia, stroke, dementia and convulsions are also disclosed.

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Sunnyvale, CA, United States of America

Daniel Warren Parish