Merck + Co., Inc.

Merck Sharp + Dohme Corp.

Daniel Warner

Mark T Goulet

Feroze Ujjainwalla

Ravi P Nargund

Thomas F Walsh

Matthew J Wyvratt

Jonathan R Young

Raman Kumar Bakshi

Lin Chu

Zhixiong Ye

Iyassu K Sebhat

Bonnie Louridas

Certain novel 4-substituted N-acylated piperidine derivatives are agonists of the human melanocortin receptor(s) and, in particular, are selective agonists of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the activation of MC-4R, such as obesity, diabetes, sexual dysfunction, including erectile dysfunction and female sexual dysfunction.

Acylated piperidine derivatives as melanocortin-4 receptor agonists

Certain novel-substituted N-acylated piperidine derivatives are agonists of the human melanocortin receptor(s) and, in particular, are selective agonists of the human melanocortin-receptor (MC-R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the activation of MC-R, such as obesity, diabetes, sexual dysfunction, including erectile dysfunction and female sexual dysfunction.

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Stoneham, MA, United States of America

Daniel Warner