University of Missouri

Advanced Separation Technologies Inc.

Advanced Separations Technologies Inc.

Daniel W Armstrong

Virgil J Flanigan

William J James

Jui-Lung Li

Kimber L Rundlett

Yubing Tang

Macrocyclic antibiotics having ring structures with at least 10 members act as separation agents in crystallization, precipitation, filtration, electrophoresis, and chromatography. The macrocyclic antibiotics include ansamacrolides, macrolides, macrocyclic peptides, polyenes and derivatives thereof. The process has been found to be especially advantageous for separation of optical isomers by electrophoresis and chromatography.

Macrocyclic antibiotics as separation agents

Macrocyclic antibiotics having ring structures with at least 10 members act as separation agents in crystallization, precipitation, filtration, electrophoresis and chromatography. The macrocyclic antibiotics include ansamacrolides, macrolides, macrocyclic peptides, polyenes and derivatives thereof. The process has been found to be especially advantageous for separation of optical isomers by electrophoresis and chromatography.

A process for producing activated carbon from agricultural residues by heating the residues to a temperature in the range of about 250.degree. C. to about 550.degree. C. to volatilize organic compounds in the residues and to carbonize the residues and further heating to activate the carbonized residues. Activated carbon produced from agricultural residues.

Activated carbon produced from agricultural residues

Process for enriching the concentration of an enantiomer (or a diastereomer) in a mixture of optically active isomers. The process includes preparing a solution containing the mixture of the optically active isomers and a chiral collector in which the chiral collector and the enantiomer (or diastereomer) are associated with each other. A gas is bubbled through a pool of the solution to form a foam, the surfaces of the bubbles in the foam having the chiral collector and the enantiomer (or diastereomer) preferentially adsorbed thereto so that the concentration ratio of the optically active isomers at said bubble surfaces differs from that in the bulk of the pool. The foam is moved vertically through a column above the pool such that during said movement at least a portion of the bubbles comprising the foam break thereby allowing liquid to drain toward the pool to provide an internal reflux within the column.

Stereoselective adsorptive bubble process

The media is an ether derivative of cyclodextrin such as a permethylated hydroxy ether of cyclodextrin or a dialkyl trifluoroacetyl ether derivative of cyclodextrin and is used in capillary gas chromatographic columns. Particular benefit is obtained using the ether derivative of cyclodextrin in a fused silica capillary.

Chiral separation media

The media is permethylated hydroxy ether of cyclodextrin and is used in capillary gas chromatographic columns.

A highly selective bonded phase material useful to separate a wide variety of organic and inorganic substances by thin layer chromatography (TLC), liquid chromatography (LC) or high performance liquid chromatography (HPLC) is produced by bonding a cyclodextrin to a silica gel by means of a specific silane linkage. The preparation of such materials and their uses are described.

Growing community of inventors

Rolla, MO, United States of America

Daniel W Armstrong