Fmc Corporation

Brookhaven Science Associates, Lcc

Brookhaven National Laboratory

Gusto Global, LLC

Fmc Agricultural Solutions A/s

Daniel Van Der Lelie

Safiyh Taghavi

John E Kibbee

Roderick G McLeod

Kevin Brost

Jaeheon Lee

Anthony Devine

Guozhi Wang

Oleg Gang

Nathan D Caldwell

Robert B Albright

Vincent J Spadafora

Anders Obel

John J Dunn

Soo-Kwan Lee

Lee Newman

Mathew Maye

Gorm V Petersen

Sylwia L Fudali-Alves

Maureen K Krause

Sean R McCorkle

Dmytro Nykypanchuk

Chelsea E Tirrell

Matthew F Pye

Roderick G Mcleod

Matthew Francis Pye

Gorm Vang Petersen

Roderick Mcleod

Kevin Ronald John Brost

Nathan Caldwell

Vincent James Spadafora

Kevin Rj Brost

John Edward Kibbee

Anthony Andrew Devine

Sylwia Lidia Fudali-Alves

Chelsea Eileen Tirrell

The present application discloses method of controlling plant pathogen(s), e.g. fungal and bacterial pathogens, on a plant, wherein a composition comprisingFCC1256 deposited as ATCC No. PTA-122162 is applied to the plant, in particular to over-ground parts of the plant. The composition may comprise iturin and fengycin in a relative weight ratio of 1.3:1.0 to 3.0:1.0. The application also discloses an agricultural composition comprising the novel strain, a carrier, a surface-active agent and optionally a buffer, and a corresponding concentrate.

FCC1256 compositions and methods of controlling plant pathogens

Methods are provided for the rational design of stable communities of microbes for benefiting the health of a host organism, including human and/or animal health. The methods describe design of microbial consortia based on providing and/or complementing key functionalities lacking or underrepresented in the microbiome of an organism having a disorder or disease as compared to healthy subjects. The consortia are designed to possess metabolic interdependencies for improved engrafting, stability and performance of the consortium. Compositions that include the designed microbial consortia are provided for treatment of disorders/diseases involving chronic inflammation, infection, and the combination of chronic inflammation and infection including inflammatory bowel disease and related disorders. The compositions are also broadly applicable for the treatment of neurological, metabolic and oncology-related conditions.

Rational design of microbial-based biotherapeutics

Methods of controlling a plant pathogen, e.g. fungal and bacterial pathogens, on a plant, are described wherein an agricultural composition comprisingFCC1256 deposited as ATCC No. PTA-122162, a carrier, a surface-active agent and optionally a buffer, and a corresponding concentrate is also described.

Compositions are provided that include a new Bacillus thuringiensis strain designated RTI545 for use in benefiting plant growth and controlling plant pests. In particular, the RTI545 strain is useful for controlling plant nematode, insect and fungal pests. The compositions include plant seeds coated with the RTI545 strain. The compositions can be applied alone or in combination with other microbial, biological, or chemical insecticides, fungicides, nematicides, bacteriocides, herbicides, plant extracts, plant growth regulators, or fertilizers. In one example, enhanced growth and insect control are provided by delivering at the time of planting a combination of a chemical insecticide such as bifenthrin and a liquid fertilizer to plants or seeds treated with RTI545.

RTI545 compositions and methods of use for benefiting plant growth and controlling plant pests

The present invention relates to a novel species ofsp. 638, and to its use in connection, for example, with a method for increasing growth in a plant, increasing biomass in a plant, increasing fruit and/or seed productivity in a plant, increasing disease tolerance and/or resistance in a plant, and increasing drought tolerance and/or resistance in a plant, as compared to a control or wild-type plant grown under identical conditions without application of the inventive method or composition. The methods include applying an effective amount of a composition, which includes an isolated culture ofsp. 638, to the plant.

sp-638 and methods of use thereof

Compositions are provided that include a newstrain designated RTI545 for use in benefiting plant growth and controlling plant pests. In particular, the RTI545 strain is useful for controlling plant nematode, insect and fungal pests. The compositions include plant seeds coated with the RTI545 strain. The compositions can be applied alone or in combination with other microbial, biological, or chemical insecticides, fungicides, nematicides, bacteriocides, herbicides, plant extracts, plant growth regulators, or fertilizers. In one example, enhanced growth and insect control are provided by delivering at the time of planting a combination of a chemical insecticide such as bifenthrin and a liquid fertilizer to plants or seeds treated with RTI545.

Compositions and methods are provided for a combination of a new strain ofRTI301 and a new strain ofRTI477, the combination having growth promoting activity and activity against plant pathogens. The compositions containing the RTI301 and RTI477 strains are useful for benefiting plant growth and/or conferring protection against a pathogenic infection when applied to plant roots, seeds, callus tissue, grafts, and cuttings. Synergistic results are observed for the combination of the strains, and the combination of strains is useful to increase yield in crops including soybean and corn. The compositions containing the combination of strains can be applied alone or in combination with other microbial, biological, or chemical insecticides, fungicides, nematicides, bacteriocides, herbicides, plant extracts, plant growth regulators, and fertilizers.

Microbial compositions and methods of use for benefiting plant growth and treating plant disease

The invention relates to the use of peptides, proteins, and other oligomers to provide a means by which normally quenched nanoparticle fluorescence may be recovered upon detection of a target molecule. Further, the inventive technology provides a structure and method to carry out detection of target molecules without the need to label the target molecules before detection. In another aspect, a method for forming arbitrarily shaped two- and three-dimensional protein-mediated nanoparticle structures and the resulting structures are described. Proteins mediating structure formation may themselves be functionalized with a variety of useful moieties, including catalytic functional groups.

Controllable assembly and disassembly of nanoparticle systems via protein and DNA agents

In some embodiments, DNA-capped nanoparticles are used to define a degree of crystalline order in assemblies thereof. In some embodiments, thermodynamically reversible and stable body-centered cubic (bcc) structures, with particles occupying &#x3c;&#x2dc;10% of the unit cell, are formed. Designs and pathways amenable to the crystallization of particle assemblies are identified. In some embodiments, a plasmonic crystal is provided. In some aspects, a method for controlling the properties of particle assemblages is provided. In some embodiments a catalyst is formed from nanoparticles linked by nucleic acid sequences and forming an open crystal structure with catalytically active agents attached to the crystal on its surface or in interstices.

DNA-guided nanoparticle assemblies

Disclosed is a method for analyzing the organismic complexity of a sample through analysis of the nucleic acid in the sample. In the disclosed method, through a series of steps, including digestion with a type II restriction enzyme, ligation of capture adapters and linkers and digestion with a type IIS restriction enzyme, genome signature tags are produced. The sequences of a statistically significant number of the signature tags are determined and the sequences are used to identify and quantify the organisms in the sample. Various embodiments of the invention described herein include methods for using single point genome signature tags to analyze the related families present in a sample, methods for analyzing sequences associated with hyper- and hypo-methylated CpG islands, methods for visualizing organismic complexity change in a sampling location over time and methods for generating the genome signature tag profile of a sample of fragmented DNA.

Genome signature tags

Growing community of inventors

Chapel Hill, NC, United States of America

Daniel Van Der Lelie