Pfizer Corporation

Other

Pfizer Products Inc.

Daniel Tyler Richter

Michael Raymond Collins

Robert Steven Kania

John Charles Kath

Pei-Pei Kung

Maria Angelica Linton

Paul Francis Richardson

Peter Qinhua Huang

Sacha Ninkovic

Robert Louis Hoffman

Aaron Craig Burns

Graham Smith

Samantha Elizabeth Greasley

Lakshmi Sourirajan Narasimhan

Michael Luzzio

Martin James Wythes

Zheng Jane Li

Scott Channing Sutton

Hui Li

Ted William Johnson

Andrew V Trask

Phuong Thi Quy Le

Robert Arnold Kumpf

Benjamin Joseph Burke

Jacqui Elizabeth Hoffman

Ketan Satish Gajiwala

Qinhua Huang

John Frederick Braganza

The present invention relates to compounds of formula (I) 

Cycloalkyl-linked diheterocycle derivatives

This invention relates to compounds of general formula (I) 

Substituted dihydroisoquinolinone compounds

The present invention relates to compounds of formula (I)  or pharmaceutically acceptable salts thereof, wherein A, L, D, R-R, w, x, y, and z are defined herein. The novel cycloalkyl-linked diheterocycle derivatives that are useful in the treatment of abnormal cell growth, such as cancer, in mammals. The present invention also relates to pharmaceutical compositions containing the compounds and to methods of using the compounds and compositions in the treatment of abnormal cell growth in mammals.

Compounds of the general formula (I): processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.

Axl inhibitors

A system for handling sample vials includes a vault for receiving a series of storage cartridges. Inside the cartridges are one or more discs providing vial recesses. In multidisc cartridges, through passages are provided to place and retrieve vials into and from the subjacent discs. A pick up device is moved until it aligns with a selected vial and the vial is pneumatically removed. A device is provided to reverse orientation of a vial moving through the system. A venturi operated system is provided including symmetrical bleed off ports to propel vials through the system without inducing excessive spinning of the vials. A piping system from a central bank to a multiplicity of analytical instruments includes a minimum number of through conduits and a diverter at each instrument location for sending the vial either to the instrument or downstream toward another diverter and instrument.

Delivery system for analytical samples

The present invention is directed to compounds of formula (I), and pharmaceutically acceptable salts thereof, their synthesis, and their use as CHK-1 inhibitors.

6 substituted 2-heterocyclylamino pyrazine compounds as CHK-1 inhibitors

A control system for a bank of analytical instruments operates the instruments as a group rather than singly. The system includes an autoloader at a sample preparation station into which an individual loads sample vials of unknown material. A second autoloader provides sample vials of known material that can be used to calibrate instruments. A computer controls the autoloader and a conveyor system to deliver a selected one of the vials to a selected instrument. The conveyor system includes a group of distributors, typically in series, to deliver a vial to any one of a large group of instruments. The conveyor system is preferably a pneumatic system including a receiver and technique for slowing the vials down when they approach the receiver. The receiver is positioned to deliver the vial to an autoinjector of the instrument. A computer monitors and communicates with the analytical instrument to obtain inputs to control components of the system.

Delivering samples to and controlling analytical instruments

The present invention relates to a method of making a compound of the formula wherein X, Xand R&#x2014;Rare as defined herein. The method includes reacting a compound of the formula with an amine of formula 3 (HNRR) in the presence of a Lewis Acid and a non-nucleophilic base. The 2,4-diamino pyrimidine moiety is a common component in a variety of biologically active drug-like molecules and pyrimidine derivatives have been found to be useful in the treatment of abnormal cell growth, such as cancer, in mammals.

Selective synthesis of CF3-substituted pyrimidines

The invention relates to succinate and malonate complexes of E-2-Methoxy-N-(3-{4-[3-methyl-4-(6-methyl-pyridin-3-yloxy)-phenylamino]-quinazolin-6-yl}-allyl)-acetamide having the following formula I: More particular the present invention relates to monosuccinate, hemisuccinate, sesquisuccinate and di-malonate complexes of formula I. The invention also relates to pharmaceutical compositions containing the succinate and malonate complexes of formula I. The invention further relates to methods of treating hyperproliferative diseases, such as cancers, in mammals, especially humans by administering the above complexes and to methods of preparing the above complexes.

Salt forms of E-2-methoxy-N-(3-{4-[3 methyl-4-(6-methyl-pyridin-3-yloxy)-phenylamino]-quinazolin-6-yl}-allyl)-acetamide and method of production

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San Diego, CA, United States of America

Daniel Tyler Richter