Abbott Laboratories Corporation

Daniel Tim-Wo Chu

David Lyon Garmaise

Edith Bernstein

Stuart Nicholas Huckin

A new chemical compound, the 12a-deoxychelocardin has been synthesized and found to be a potent antibacterial. It can also be used as an intermediate for the preparation of a number of modified chelocardin analogs that are similarly active as antibacterials, e.g. the compounds carrying different substituents in the D-ring.

12A-Deoxy chelocardin

A specific anilino derivative of chelocardin having high antibiotic activity is described. This new derivative shows unusually low toxicity and consequently a very high therapeutic index as chemotherapeutic agent against gram-negative organisms.

3,4-Dimethyl-5-isoxazolylsulfamylaniline

A number of specific anilino derivatives of chelocardin having high antibiotic activity are described. These new derivatives show unusually low toxicity and consequently a very high therapeutic index as chemotherapeutic agents against gram-negative organisms.

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Greenfield Park, Canada

Daniel Tim-Wo Chu