Glaxosmithkline Intellectual Property Development Limited

Glaxo Group Limited

Glaxosmithkline Intellectual Property (no.2) Limited

Daniel Terence Tape

Keith Biggadike

Diane Mary Coe

Aurelie Cecile Champigny

Deborah Needham

Stephen Allan Smith

Ian B Campbell

John Martin Pritchard

Gianpaolo Bravi

Simon Peace

Robert Charles Wheeler

Ian Baxter Campbell

A compound of formula (1) Or a pharmaceutically acceptable salt and tautomers thereof, compositions, combinations and medicaments containing said compounds and processes for their preparation. The invention also relates to the use of said compounds, combinations, compositions and medicaments, in the treatment of diseases and conditions in which modulation of STING (Stimulator of Interferon Genes) is beneficial, for example inflammation, allergic and autoimmune diseases, infectious diseases, cancer and as vaccine adjuvants.

Cyclic di-nucleotides as modulators of STING

Compounds of formula (I) and salts thereof: wherein Ris hydrogen, methyl or &#x2014;(CH)OR, Ris methyl or &#x2014;(CH)OR, or Rand R, together with the nitrogen atom to which they are attached, are linked to form a 5- or 6-membered heterocyclyl wherein the 6-membered heterocyclyl is optionally substituted by two hydroxy substituents; Rand Rare each independently hydrogen or methyl; and n is an integer having a value of 5 or 6, are inducers of human interferon. Compounds which induce human interferon may be useful in the treatment or prevention of various disorders, for example the treatment or prevention of allergic diseases and other inflammatory conditions, for example allergic rhinitis and asthma, infectious diseases and cancer, and may also be useful as vaccine adjuvants.

Pyrrolo[3,2-D]pyrimidine derivatives as inducers of human interferon

A compound of formula (I) or a pharmaceutically acceptable salt and tautomers thereof, compositions, combinations and medicaments containing said compounds and processes for their preparation. The invention also relates to the use of said compounds, combinations, compositions and medicaments, in the treatment of diseases and conditions in which modulation of STING (Stimulator of Interferon Genes) is beneficial, for example inflammation, allergic and autoimmune diseases, infectious diseases, cancer, pre-cancerous syndromes and as vaccine adjuvants.

Cyclic dinucleotides useful for the treatment of inter alia cancer

A compound of formula (I) wherein or a pharmaceutically acceptable salt thereof.

N-cyclobutyl-imidazopyridine-methylamine as TRPV1 antagonists

The present invention relates to compounds of formula (I): or pharmaceutically acceptable salts or solvates thereof, processes for their preparation, pharmaceutical compositions containing these compounds, and their use in the treatment of allergic disorders, such as allergic rhinitis and asthma.

Bicyclic imidazole as DP1 receptor antagonists

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Stevenage, United Kingdom

Daniel Terence Tape