Adamed Sp. Z O.o.

Daniel Sulikowski

Zbigniew Majka

Katarzyna Ewa Rusin

Krzysztof Kurowski

Katarzyna Joanna Matusiewicz

Tomasz Stawinski

Piotr Kowalczyk

Andrzej Wojciech Sawicki

Dominik Daniel Kludkiewicz

Andrzej Sawicki

The invention relates to new compounds, being 3-phenylpropionic acid derivatives of formula I wherein W represents COOH group or its bioisosters, or &#x2014;COO&#x2014;C-C-alkyl group; Y represents NH, N&#x2014;C-C-alkyl, O, or S; Z represents NH, N&#x2014;C-C-alkyl, N-aryl, N-heteroaryl, S, or O; X represents O, S, NH, N&#x2014;C-C-alkyl, N-aryl, NSO&#x2014;C-C-alkyl, N&#x2014;SO-aryl, or N&#x2014;SO-heteroaryl; R, to Reach independently represent hydrogen atom or a substituent defined in the description; A is as defined in the description; n represents an integer from 0 to 4, inclusive; and pharmaceutically acceptable salts thereof. The compounds are the ligands of PPAR-gamma receptor and are useful as medicaments. 

3-phenylpropionic acid derivatives

The invention relates to a method of treatment and/or prophylaxis of diseases and conditions mediated by peroxysome proliferator-activated receptor gamma (PPAR&#x3b3;) in a mammal subject in need thereof, said method comprising administration to said mammal a compound of formula (I) or a pharmaceutically acceptable salt thereof in a therapeutically or prophylactically effective amount  wherein in formula (I) W represents a COOH group or its bioisosters, or COO&#x2014;C-C-alkyl group; Y represents NH or N&#x2014;C-C-alkyl; Z represents NH, N&#x2014;C-C-alkyl, N-aryl, N-heteroaryl, S, or O; X represents O, S, NH, N&#x2014;C-C-alkyl, N-aryl, NSO&#x2014;C-C-alkyl, N&#x2014;SO-aryl, or N S0-heteroaryl; Rto Reach independently represents a hydrogen atom or a substituent defined in the description; A is as defined in the description; n represents an integer from 0 to 4, inclusive. The compounds of formula (I) are the ligands of PPAR-gamma receptor.

The invention relates to new compounds, being 3-phenylpropionic acid derivatives of formula I wherein W represents COOH group or its bioisosters, or &#x2014;COO&#x2014;C-C-alkyl group; Y represents NH, N&#x2014;C-C-alkyl, O, or S; Z represents NH, N&#x2014;C-C-alkyl, N-aryl, N-heteroaryl, S, or O; X represents O, S, NH, N&#x2014;C-C-alkyl, N-aryl, NSO&#x2014;C-C-alkyl, N&#x2014;SO-aryl, or N&#x2014;SO-heteroaryl; Rto Reach independently represent hydrogen atom or a substituent defined in the description; A is as defined in the description; n represents an integer from 0 to 4, inclusive; and pharmaceutically acceptable salts thereof. The compounds are the ligands of PPAR-gamma receptor and are useful as medicaments 

The invention relates to new compounds, being 3-phenylpropionic acid derivatives of formula I wherein W represents COOH group or its bioisosters, or &#x2014;COO&#x2014;C&#x2013;C-alkyl group; Y represents NH, N&#x2014;C&#x2013;C-alkyl, O, or S; Z represents NH, N&#x2014;C&#x2013;C-alkyl, N-aryl, N-heteroaryl, S, or O; X represents O, S, NH, N&#x2014;C&#x2013;C-alkyl, N-aryl, NSO&#x2014;C&#x2013;C-alkyl, N&#x2014;SO-aryl, or N&#x2014;SO-heteroaryl; R, to Reach independently represent hydrogen atom or a substituent defined in the description; A is as defined in the description; n represents an integer from 0 to 4, inclusive; and pharmaceutically acceptable salts thereof. The compounds are the ligands of PPAR-gamma receptor and are useful as medicaments. 

The invention relates to new compounds, 3-phenylpropionic acid derivatives of formula (I) wherein W represents COOH group or its bioisosters, or &#x2014;COO&#x2014;C&#x2013;C-alkyl group; Y represents NH, N&#x2014;C&#x2013;C-alkyl, O, or S; X represents O, S, NH, N&#x2014;C&#x2013;C-alkyl, N-aryl, NSO&#x2014;C&#x2013;C-alkyl, N&#x2014;SO-aryl, or N&#x2014;SO-heteroaryl; Rto Reach independently represents hydrogen atom or a substituent defined in the description; A is as defined in the description; n represents an integer from 0 to 4, inclusive; and pharmaceutically acceptable salts thereof. The compounds are the ligands of PPAR-gamma receptor and are useful as medicaments 

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Gubin, Poland

Daniel Sulikowski