Novartis Ag

Daniel Steven Palacios

Keith Jendza

Michael David Shultz

Fan Yang

James Neef

Edward Charles Hall

Xin Chen

Nancy Labbe-Giguere

Ming Qian

Kevin Matthew Gardinier

Amy Calhoun

Christopher G Thomson

Kate Yaping Wang

Natalie Alysia Dales

John Ryan Kerrigan

George Scott Tria

Paul Gormisky

Provided herein are compounds according to Formula (I) or a pharmaceutically acceptable salt thereof, wherein R, R, R, R, and Rare defined herein. Also provided herein are pharmaceutical compositions comprising a compound of Formula (I) as well as the use of such compounds as M4 receptor agonists.

2-azaspiro[3.4]octane derivatives as M4 agonists

The present disclosure provides a compound of formula (I): or a pharmaceutically acceptable salt thereof, and its therapeutic uses for activating a growth factor pathway, promoting wound healing, promoting tissue repair, and treating hearing loss, skeletal muscle loss, organ degeneration, tissue damage, neurodegeneration, and muscular atrophy. The disclosure further provides pharmaceutical compositions and combinations. The present disclosure also relates to the use of such compounds for research or other non-therapeutic purposes.

Indole derivatives and uses thereof

Growing community of inventors

Cambridge, MA, United States of America

Daniel Steven Palacios