Delcath Systems, Inc.

Other

Wyeth

Daniel Stephen Johnston

William M Appling

Jacques Chammas

Samantha J Barton

Eamonn P Hobbs

Charles Zacharchuk

Jay Marshall Feingold

Anna Berkenblit

Christina Marie Coughlin

Andrew Louis Strahs

Michael A Quesada

Charles Michael Zacharchuk

A filter apparatus for removing small molecule chemotherapy agents from blood is provided. The filter apparatus comprises a housing with an extraction media comprised of polymer coated carbon cores. Also provided are methods of treating a subject with cancer of an organ or region comprising administering a chemotherapeutic agent to the organ or region, collecting blood laded with chemotherapeutic agent from the isolated organ, filtering the blood laden with chemotherapeutic agent to reduce the chemotherapeutic agent in the blood and returning the blood to the subject.

Apparatus for removing chemotherapy compounds from blood

A method for optimal selection of cytotoxic agents for organ or region specific therapy that includes extracorporeal filtration of the cytotoxic agent from blood drained from the organ or region being treated and return of the filtered blood to a mammal is disclosed.

Method of selecting chemotherapeutic agents for an isolated organ or regional therapy

A cut-point in the quantitative measurement of PTEN protein expression that accurately identifies tumors with two inactivated alleles of the PTEN gene. Patients with a normalized PTEN score of PTEN null will be treated with a pan-ErbB tyrosine kinase inhibitor. A normalized PTEN protein expression score is obtained by comparing the tumor PTEN OD expression value with the non-malignant PTEN OD expression value.

Cut-point in PTEN protein expression that accurately identifies tumors and is predictive of drug response to a pan-ErbB inhibitor

A staple removal tool includes an elongated handle mounting a U-shaped cover member supporting a U-shaped base member formed with a forwardly projecting staple lifter tongue. A crimping arm is pivoted on the base member for movement toward and away from the staple lifter tongue and is actuated by a hand lever located under the handle and pivotally secured at its forward end to the cover member. A spring loaded link member is attached at one end to the hand lever and at the opposite end to the crimping arm, whereby pivoting of the handle lever effects pivotal movement of the crimping arm. A crimping bar is secured to and spaced from the base member to receive the clamping arm between them. The staple lifter tongue engages under the bridge portion of a staple, such as a roofing staple, and leveraging of the handle pulls the staple from its wood anchor. If the staple breaks, or if only one leg pulls out of the wood, the upwardly projecting length of staples still anchored in wood is placed alongside the confronting sides of the tongue and crimping bar and the hand lever manipulated to pivot the clamping arm into the space between the tongue and crimping bar, whereby to bend the staple leg to U-shape around the clamping arm and secure it against release, allowing the handle to leverage the resistant leg out of the wood.

Staple removal tool

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Trappe, PA, United States of America

Daniel Stephen Johnston