Micromass UK Limited

Daniel Simon

Steven Derek Pringle

Daniel Szalay

Lajos Godorhazy

Zoltan Takats

Emrys Jones

Julia Balog

Tamas Karancsi

Keith George Richardson

Michael Raymond Morris

James Ian Langridge

Frances Bolt

Phillip Robert Bennett

David Alan MacIntyre

Pamela Pruski

Ian David Trivett

Stephen O'Brien

Alvin Chua

Tamás Karancsi

Anthony Hesse

Zoltán Takáts

Matt Henderson

Zoltan Takáts

A method of analysis using mass and/or ion mobility spectrometry or ion mobility spectrometry is disclosed comprising: using a first device to generate aerosol, smoke or vapour from one or more regions of a first target of biological material; and mass and/or ion mobility analysing and/or ion mobility analysing said aerosol, smoke, or vapour, or ions derived therefrom so as to obtain first spectrometric data. The method may use an ambient ionisation method.

Tissue analysis by mass spectrometry or ion mobility spectrometry

A method of analysis using mass spectrometry and/or ion mobility spectrometry is disclosed. The method comprises: using a first device to generate smoke, aerosol or vapour from a target comprising or consisting of a microbial population; mass analysing and/or ion mobility analysing said smoke, aerosol or vapour, or ions derived therefrom, in order to obtain spectrometric data; and analysing said spectrometric data in order to analyse said microbial population.

Spectrometric analysis of microbes

A method is disclosed comprising providing a biological sample on a swab, directing a spray of charged droplets onto a surface of the swab in order to generate a plurality of analyte ions, and analysing the analyte ions.

Rapid evaporative ionisation mass spectrometry ('REIMS') and desorption electrospray ionisation mass spectrometry ('DESI-MS') analysis of swabs and biopsy samples

An apparatus for performing ambient ionization mass and/or ion mobility spectrometry is disclosed. The apparatus comprises a substantially cylindrical, tubular, rod-shaped, coil-shaped, helical or spiral-shaped collision assembly; and a first device arranged and adapted to direct analyte, smoke, fumes, liquid, gas, surgical smoke, aerosol or vapor onto said collision assembly.

Collision surface for improved ionisation

A method of mass spectrometry or ion mobility spectrometry is disclosed comprising: providing an analyte; supplying a matrix compound to said analyte such that said analyte dissolves in said matrix; forming first droplets of the dissolved analyte; and colliding said first droplets with a collision surface. The use of matrix improves the analyte ion signal.

Ionisation of gaseous samples

A method of analysis is disclosed comprising providing a sample on an insulating substrate such as a petri dishand contacting e.g. the rear surface of the insulating substrate with a first electrode. The method further comprises contacting the sample with a second electrodeand applying an AC or RF voltage to the first and second electrodesin order to generate an aerosol from the sample.

Capacitively coupled REIMS technique and optically transparent counter electrode

An apparatus for performing ambient ionisation mass and/or ion mobility spectrometry is disclosed. The apparatus comprises a substantially cylindrical, tubular, rod-shaped, coil-shaped, helical or spiral-shaped collision assembly; and a first device arranged and adapted to direct analyte, smoke, fumes, liquid, gas, surgical smoke, aerosol or vapour onto said collision assembly.

A method is disclosed comprising obtaining physical or other non-mass spectrometric data from one or more regions of a target using a probe. The physical or other non-mass spectrometric data may be used to determine one or more regions of interest of the target. An ambient ionisation ion source may then used to generate an aerosol, smoke or vapour from one or more regions of the target.

Physically guided rapid evaporative ionisation mass spectrometry ('REIMS')

A method of analysis is disclosed comprising providing a sample on an insulating substrate such as a petri dish () and contacting e.g. the rear surface of the insulating substrate with a first electrode (). The method further comprises contacting the sample with a second electrode () and applying an AC or RF voltage to the first and second electrodes () in order to generate an aerosol from the sample.

A method is disclosed comprising obtaining or acquiring chemical or other non-mass spectrometric data from one or more regions of a target using a chemical sensor. The chemical or other non-mass spectrometric data may be used to determine one or more regions of interest of the target. An ambient ionisation ion source may then be used to generate aerosol, smoke or vapour from one or more regions of the target.

Chemically guided ambient ionisation mass spectrometry

A method is disclosed comprising obtaining or acquiring image or other data from one or more regions of a target using an imaging sensor. The image or other data may then be used to determine one or more regions of interest of the target. An ambient ionisation ion source may then be used to generate aerosol, smoke or vapour from one or more regions of the target.

Growing community of inventors

Morichida, Hungary

Daniel Simon