Leland Stanford Junior University

Genentech, Inc.

F. Hoffmann-la Roche Ag

Daniel Shin-Yu Chen

Mark M Davis

Hartmut Koeppen

Daniel Lewis Kraft

Patrick O Brown

Priti Hegde

Marcin Kowanetz

Yoav Soen

Provided herein are biomarkers for the treatment of pathological conditions, such as cancer, and method of using PD-1/PD-L1 pathway antagonists. In particular, provided are biomarkers for patient selection and prognosis in cancer, as well as methods of therapeutic treatment, articles of manufacture and methods for making them, diagnostic kits, methods of detection and methods of advertising related thereto.

Biomarkers and methods of treating PD-1 and PD-L1 related conditions

T cells are profiled with respect to their expression of antigen receptor. The cells are arrayed on a planar or three-dimensional substrate through binding to immobilized or partially diffused MHC-antigen complexes. The cells may further be characterized with respect to their ability to respond to external stimulus in the microenvironment. External stimuli include cell-cell interactions, response to factors, and the like.

MHC-antigen arrays for detection and characterization of immune responses

Growing community of inventors

Burlingame, CA, United States of America

Daniel Shin-Yu Chen