Other

University of California

Daniel Shin

Antoni Ribas

Steven Krupnick

Casey Cuvan Clark

Jesse Zaretsky

Angel Garcia-Diaz

Blanca Homet Moreno

Disclosed herein are methods of treating or assessing cancer in a subject wherein it has been determined whether the cancer comprises a loss of function mutation or disruption in an immune pathway. The loss of function mutation or disruption can be in JAK1 or JAK2. The loss of function mutation or disruption can be in B2M. The methods can include administering an immune checkpoint therapy such as anti-PD1 or anti-PDL1. The methods can include administering an alternative therapy to an immune checkpoint therapy. In some aspects, the method includes determining whether the cancer comprises a loss of function mutation or disruption in an immune pathway.

Methods for immunotherapy-based treatment and assessment of cancer

Disclosed are apparatus and a method for sterilizing an internal surface of a lumen in a medical instrument, e.g., an endoscope. The apparatus is in the form of an elongated UVC light guide, e.g., an optic fiber, having a central longitudinal axis and which is configured to be extended down the lumen in the instrument, and a housing including a source of UVC light. The UVC light guide includes a distal end portion and is configured to carry UVC light internally from the source of UVC light to the distal end portion. The distal end portion includes a reflective surface for directing the UVC light radially outward with respect to the central longitudinal axis, whereupon when the UVC light guide is extended into the lumen in the medical instrument the radially directed UVC light impinges the internal surface of the lumen to sterilize it.

Apparatus and method of sterilizing lumens in medical instruments

Growing community of inventors

Los Angeles, CA, United States of America

Daniel Shin