Vanderbilt University

Daniel Shae

John T Wilson

Dinh Chuong Nguyen

A graft copolymer and a method of delivering an active agent to a subject are provided. The graft copolymer includes a polymer backbone, a hydrophilic segment grafted to the polymer backbone, a pH-responsive segment grafted to the polymer backbone, and an endosomal disruption segment grafted to the polymer backbone. The method of delivering an active agent to a subject includes encapsulating the active agent with the graft copolymer and administering the encapsulated active agent to the subject.

Graft copolymers, methods of forming graft copolymers, and methods of use thereof

A diblock copolymer, polymer vesicle, and method of forming a polymer vesicle are provided. The diblock polymer includes a hydrophilic first block and a second block including amine containing monomers and hydrophobic monomers. The polymer vesicle includes a diblock copolymer with a hydrophilic first block and a second block including amine containing monomers and hydrophobic monomers, and at least one active agent loaded in the polymer vesicle. The second block forms an inner hydrophobic domain of a vesicle membrane and the hydrophilic block forms a corona facing the exterior and aqueous interior of the vesicle membrane, the corona providing an outer shell that stabilizes the vesicle in aqueous media. The method of forming the polymer vesicle includes synthesizing the diblock copolymer through a polymerization technique selected from the group consisting of addition polymerization, condensation polymerization, and a combination thereof, providing at least one active agent, and assembling the polymer vesicle, the diblock copolymer including a hydrophilic first block and a second block with amine containing monomers and hydrophobic monomers.

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Nashville, TN, United States of America

Daniel Shae