University of California

University of Pennsylvania

Daniel Sebastian Pan

Majid Sarrafzadeh

Vladimir R Muzykantov

Samir Suresh Mitragotri

Jacob Brenner

Jason Holmes

Bita Zadeh

Jordan Mendler

Simran Basi

Jacob Myerson

Diego Villasenor

Compositions comprising a red blood cell (RBC) having non-toxically coupled thereto a nanoparticle having a low shear modulus or low Young's modulus of less than 10 MPa and containing a drug are provided. In one embodiment, the nanoparticles are optionally coated with protein. In another embodiment, the nanoparticle has no cell-specific targeting moiety or tissue-specific targeting moiety or organ-specific targeting moiety associated therewith. Methods of delivering selected drugs to target organs use these compositions both in vivo and ex vivo treatment of disease and for imaging.

Methods and compositions for drug delivery

Devices, methods, and systems for monitoring, classifying and encouraging activity through the use of an accelerometer or other sensor in a toy or other accessory (such as a backpack or watch) that records activity are disclosed. The activity is classified, using various motion classification algorithms, to determine the specific types and amount of activities performed and the times and duration for which they were performed. The classified data is used in the rest of the system, which allows users to view activity history, recommendations for how to improve health, and play games in which the player's game performance is effected by their activity levels. In games and on the website, feedback is also given to users to encourage and reward exercise, while handicapping users that are not active.

Devices, systems, and methods for monitoring, classifying, and encouraging activity

Growing community of inventors

Arcadia, CA, United States of America

Daniel Sebastian Pan