International Business Machines Corporation

The University of Melbourne

The Florey Institute of Neuroscience and Mental Health

Daniel Scott

John Michael Wagner

Stefan Harrer

Priscilla Racquel Rogers

Natalie J Gunn

Ross Bathgate

Stan Skafidas

Matthew Downton

Matthew Downtown

A mechanism is provided for utilizing a nanodevice to distinguish molecules with different structure. The molecules translocate through or across a nanochannel filled with a electrolyte solution. An electrical signal through the nanochannel is measured for every translocation event. Inner surfaces of the nanochannel include a functional layer, which is a coating to functionalize the nanochannel, in which the functional layer is configured to interact with predetermined ones of the molecules during translocation events. It is determined that a combination of at least two different molecules is formed based on predetermined ones of the molecules interacting with the functional layer to change the electrical signal and/or change a translocation time for the translocation event.

Methods for determining binding capability of target ligands with G protein-coupled receptors using translocation through nanochannels

Modifying single proteins (GPCR), ligands, and nanopore surfaces to create binding-induced molecular changes of protein-ligand complexes detected in nanochannel translocation

Growing community of inventors

Victoria, Australia

Daniel Scott