Medibeacon Inc.

Lohmann Gmbh & Co Kg

Norbert Gretz

Gretz, Norbert

Gunther, Jurgen

Friedemann, Jochen

Neudecker, Sabine

Konig, Stefan

Pill, Johannes

Schock-kusch, Daniel

Heinrich, Ralf

Daniel Schock-Kusch

Johannes Pill

Christian Schildknecht

Soichi Watanabe

Wolfgang Wach

Felix Eickemeyer

Ralf Heinrich

Jae Hyung Hwang

Thomas Rose

Juergen Guenther

Stefan Koenig

Thomas Walter

Jürgen Hesser

Maliha Sadick

Sabine Neudecker

Jochen Friedemann

Ralf Nittenwilm

Michael Herbertz

Jochen Friedmann

Stefan Konig

Juergen Hesser

Jae Hyuug Hwang

The present invention relates to a method for determining an organ function in a subject, comprising the steps of: providing a first concentration-time curve obtained by transcutaneously measuring in a body fluid at a first position background fluorescence in at least one first time point and fluorescence of an indicator compound in at least a second, a third, a fourth, a fifth, and a sixth time point; providing a second concentration curve obtained by transcutaneously measuring in a body fluid at a second position background fluorescence in at least one seventh time point and fluorescence of an indicator compound in at least a eighth, a ninth, a tenth, an eleventh, and a twelfth time point; fitting the first and the second concentration curve into a kinetic model representing at least four diffusion compartments; and thereby determining an organ function in a subject. The invention further relates to a device for determining an organ function according to the method of the present invention, said device comprising a first sensor for transcutaneously measuring fluorescence of an indicator at a first position, a second sensor for transcutaneously measuring fluorescence of an indicator at a second position; and a data processing unit for fitting the values obtained by the sensors into a kinetic model of one of the preceding claims. The present invention also relates to a kit comprising a device of the present invention and an indicator compound, as well as to a computer or computer network comprising at least one processor, wherein the computer or computer network is adapted to perform the method according to the present invention.

Transcutaneous organ function measurement

A sensor plaster () for the transcutaneous measurement of an organ function, more particularly of a kidney function, is proposed. The sensor plaster () comprises at least one flexible carrier element () having at least one adhesive surface () which can be stuck onto a body surface. Furthermore, the sensor plaster () comprises at least one radiation source, more particularly a light source (), wherein the radiation source is designed to irradiate the body surface with at least one interrogation light (). Furthermore, the sensor plaster () comprises at least one detector () designed to detect at least one response light () incident from the direction of the body surface.

Disclosed herein is a method for the transcutaneous determination of organ function in a subject. The method includes administering a fluorescent indicator substance to the subject, determining a first and a second concentration-time curve of the fluorescent indicator in a body fluid of the patient and fitting the concentration-time curves to a four compartment kinetic model.

The present invention pertains to a functional patch to be affixed to the skin, with the aim of measuring metabolic disruptions to organs, and general organ functions, of kidneys, liver, heart, pancreas and muscles (lactate), for example&#x2014;more particularly it concerns the measurement of the glomerular filtration rate (GFR)&#x2014;and also to a method for producing a functional patch of this kind.

Adhesive functional strip for transcutaneous fluorescence measurement

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Mannheim, Germany

Daniel Schock-Kusch