Salvia Bioelectronics B.v.

Daniel Schobben

Hubert Martens

Marjolein Schets

Wim Pollet

A method includes configuring, by a computing device, stimulation settings for each electrode in an at least one electrode array in physical contact with a patient, the stimulation settings having adjustable parameters comprising frequency, pulse width, and amplitude, obtaining, by the computing device, feedback information from the patient, and automatically adjusting, by the computing device, at least one of the adjustable parameters based on the feedback information from the patient.

System and method for self-programming stimulation settings

An implantable restraint is provided that includes an opening-configured to receive a tissue anchor; a pair of protrusions between the opening and a distal edge, providing an anchor resistance to a longitudinal force; where the pair of protrusions are further configured to separate by a distance approximately equal to the tissue anchor when the longitudinal force exceeds a first predetermined threshold, such that the pair of protrusions moves past the tissue anchor. By providing one or more openings extending through the substrate, the growth of tissue which naturally occurs after implantation is utilized to assist in securing the implantable restraint at the implantation site. By providing the pair of protrusions configured to provide resistance, a high degree of control of the restraining force and the explantation force is provided.

Implantable restraint and stimulation device configured for explantation

Implants must protect against implant contamination and corrosion of electronics. However, when electrical components are fitted to flexible substrates, failure can occur at electrical connections. An implant comprises: a flexible substrate; a first and second electrical component at a first and second position, electrically connected through an interconnect layer; a first and second component cover, separately encapsulating the first and second component to resist the ingress of body fluids into the component positions; wherein the flexible substrate allows a relative change in disposition between the first component cover and the second component cover. One or more electrodes are provided at a third position. By encapsulating each component separately, the position of force/tension is moved away from the component attachment position to a point somewhere between the component positions. By disposing one or more electrode away from the components, the ingress is further restricted.

Implantable medical device with two or more encapsulated components

In general, implantation of neurostimulation systems or device includes subcutaneous or percutaneous placement of at least the electrodes. Preferred are minimally invasive implantation procedures, systems and devices that can reliably operate for extended periods, and systems and devices providing a high degree of comfort for the subject. The implantation specialist may need to address adequate placement of the electrodes with respect to the nerve tissue to be stimulated, and to choose between one or more convenient locations for the elements of the system or device. Methods are provided comprising forming a firstand secondincision on opposite sides of a target location, and introducing a first introducer sheathunder the skin with a maximum internal transverse cross-section less than the further maximum transverse cross-sectionof an implantable stimulator. Such a method is advantageous if the maximum transverse cross-sectionof the further portion is at least 1.2 times greater than the maximum transverse cross-sectionof the first portion&#x2014;the dimensions of the implantation tools may be reduced. A further method is provided wherein the first portionwith at least two electrodesis introduced in the skin layers between the nerve tissueto be stimulated and above or in the aponeurosis layer By being implanted deeper and/or more accurately, comfort and/or reliability for the subject may be improved. In addition, the chance that the stimulator is implanted under the nerve tissue is greatly increased.

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Eindhoven, Netherlands

Daniel Schobben