Centre National De La Recherche Scientifique

Centre Technique Du Papier

Biovector Therapeutics, S.a.

A Et S Biovecteurs

Institut Pasteur

Bio Serae Laboratoires S.a.

Biovectors Therapeutics S.a.

Institute National Polytechnique De Toulouse

Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung E.V.

Institut National Polytechnique De Toulouse

Cellulotech Inc

Samain, Daniel

Daniel Samain

Li Ding

Pascal E Delrieu

David Guerin

Ignacio De Miguel

Monique Cervilla

Frederique Nguyen

Karim Ioualalen

Laurent Imbertie

Nicoleta Camelia Stinga

Valerie Rieumajou

Jaouad Meniali

Joelle Gibilaro

Suzelei Montanari

Didier Betbeder

Pierre Perrin

Roger Kravtzoff

Michel Major

Jean-Stéphane Condoret

Camélia Stinga

Michel Vignon

Nathalie Castignolles

Michel Degre

Marianne Peyrot

Edith Cohen

Jean-Louis Bec

Roselyne Dirson

André Lemaitre

Laurent Lyannaz

Nadine Soulet

Corinne Soler

Jean-Luc Guillouty

Markus Schmid

Nadine Candelotto

Corinne Segreto

Klaus Noller

Fr&eacute;d&eacute;rique N'guyen

Igancio De Miguel

Jean-Stephane Condoret

Andre Lemaitre

The invention relates to a machine for chromatogenous grafting treatment of a scrolling substrate (S) having a hydroxylated face (Fh), comprising:

Machine and treatment process via chromatogenous grafting of a hydroxylated substrate

A process for treating a solid substrate coupled to a polyol, wherein said polyol bears free hydroxyl groups, comprising the grafting of at least one fatty acid having an aliphatic chain comprising at least 12 carbon atoms onto said solid substrate coupled to a polyol by esterification of at least one free hydroxyl group of said polyol.

Barrier film with molecular expansion under strain

Film having liquid-water, grease, gas and water-vapor barrier properties, comprising a PVA film grafted on the surface with a fatty acid.

Film having water, grease, gas and water vapor barrier properties

New cellulose-based composites and production methods thereof, comprising partial peracetylation of cellulose fibers having a degree of crystallinity less than 80%.

Cellulose-based composite materials

The invention relates to a method for the controlled oxidation of oligo- and/or polysaccharides containing free &#x2014;CHOH primary hydroxyl groups, using an oxidizing agent. The invention is characterized in that the oxidation reaction is performed in a densified fluid which is inert in relation to the oxidizing agents employed. The invention is suitable for use, for example, in the food, paint, paper, textile, agricultural and pharmaceutical industries, in the medical, biomedical or paramedical fields, in the surgical field, in the cosmetic industry and as agents for the complexing or sequestering of metal ions, heavy metals and radioactive elements in the nuclear industry.

Method for the controlled oxidation of polysaccharides

A synthetic particulate vector comprising a non-liquid hydrophilic nucleus which does not have an external lipid layer grafted thereon. A method for preparing a particulate vector by encapsulating an ionizable active principle, vectors obtainable through said method, and pharmaceutical, cosmetological or food compositions containing such vectors are also disclosed.

Synthetic particulate vectors and preparation process

A biodegradable particulate vector for transporting biologically active molecules is prepared containing a nucleus formed of a cross-linked polysaccharide or oligosaccharide matrix having grafted ionic ligands, a layer of fatty acid compounds covalently bonded to the nucleus and a layer of phospholipids hydrophobically bonded to the layer of fatty acid compounds. Dextran, cellulose or starch may be cross-linked with epichlorohydrin to form a cross-linked polysaccharide matrix. Ionic ligands may be grafted using an acidic compound such as succinic acid, phosphoric acid or phosphorous oxychloride, or a basic compound such as choline, hydroxycholine, 2-(dimethylamino)ethanol or 2-(dimethylamino) ethylamine fastened onto the grafted acidic compound. Phosphoric acid or phosphorous oxychloride in one step provide both cross-linking and ionic ligands. Co-cross-linking can be obtained using a protein such as keratin, collagen or elastase. The vector may be prepared by reacting succinic acid monochloride with a cross-linked polysaccharide matrix to graft succinic acid onto the matrix to form the nucleus having ionic ligands, grinding the nucleus to a size between 10 .mu.nm and 10 .mu.m, drying, coupling fatty acid compounds to the nucleus and hydrophobically bonding phospholipids to the fatty acid compounds. After coupling the fatty acid compounds and before bonding the phospholipids, a molecule having biological activity may be added. The succinic acid monochloride is preferably prepared by reacting succinic acid dichloride with free succinic acid to form pure crystalline succinic acid monochloride.

Biodegradable particulate vector for transporting molecules having

Particulate vector and pharmaceutical composition containing it

A biodegradable particulate vector for transporting biologically active molecules is prepared containing a nucleus for containing a biologically active molecule, a first layer of fatty acid compounds covalently bonded to the nucleus and a second layer of phospholipids hydrophobically bonded to the first layer. The nucleus is between 10 nm and 10 .mu.m in size and is formed of a cross-linked polysaccharide or oligosaccharide matrix onto which ionic ligands are uniformly grafted. The cross-linked polysaccharide may be dextran, cellulose or starch cross-linked with epichlorohydrin. The ligand may be an acidic compound selected from succinic acid, phosphoric acid, citric acid, glycine, alanine, glutamic acid and aspartic acid, or a basic compound such as choline, hydroxycholine, 2-(dimethylamino)ethanol or 2-(dimethylamino)ethylamine fastened onto the matrix via the acidic compound. The polysaccharide or oligosaccharide may be co-cross-linked with a protein such as keratin/collagen or elastase. The vector may be prepared by reacting succinic acid monochloride in aqueous solution with a cross-linked polysaccharide or oligosaccharide matrix to graft succinic acid onto the matrix to form the nucleus, grinding the nucleus to a size between 10 nm and 10 .mu.m, drying the ground nucleus, coupling fatty acid compounds to the nucleus to form a first layer and hydrophobically bonding phospholipids to the first layer to form a second layer. The succinic acid monochloride is preferably prepared by reacting succinic acid dichloride with free succinic acid to form pure crystalline succinic acid monochloride.

Particle for use especially as a fat substitute, characterized in that it includes an insoluble hydrophile matrix, surrounded by a hydrophobic layer of fatty acids bound to the matrix by covalent bonds and capable of interacting with lipidic or amphiphilic compounds. The invention also concerns a composition for use as a fat substitute and a process for the preparation of such particles.

Particle for use as a milk fat globule substitute, composition

The invention relates to a process for the preparation of a particulate antimicrobial product from the LP system of the lactoperoxidase enzyme/oxygen donor/oxidizable substrate (if needed). The process comprises bonding the lactoperoxidase enzyme to a particulate carrier comprising a polysaccharide nucleus, a first lipidic layer and a second phospholipidic layer in such a manner that the enzyme molecules are inserted into this second layer and/or into the first layer. The product according to the invention is obtained by then conditioning in a non-aqueous medium the aforesaid particulate vector and the molecules of the LP system not integrated into said vector. The process of the invention permits adjusting the diffusability of the product and its mobility as a function of the intended applications, without destruction of the LP system.

Process for the preparation of a particulate antimicrobial product,

Particulate vector useful in particular for the transport of molecules

Growing community of inventors

Toulouse, France

Daniel Samain