Ge Healthcare Bio-sciences Ab

Cytiva Sweden Ab

Cytiva Bioprocess R&d Ab

Ge Healthcare Bioprocess R&d Ab

Daniel Salomonsson

Manoj Kumar Ramakrishna

Klaus Gebauer

Per Uselius

Mats Lundkvist

Per Lofving

Petter Bennemo

Per LÖFVING

Disclosed is a chromatographic separation column assembly () comprising a column cylinder () having a cylinder wall () including an inner wall surface () partially defining a column volume (), and a column component () insertable into to the cylinder (), wherein at least an edge region () of the column component is intended to be in contact or adjacent a part of the inner wall surface () in use, the edge region and the contacting or adjacent part of inner wall surface each being formed from a compatible heat fusible material or materials, and wherein at least the cylinder wall in the area of the contacting or adjacent part of the inner wall is formed from a material which allows transmission of the light energy needed to cause said fusing of the adapter plate edge region to the inner wall surface.

Chromatography column and method of assembling the same

A parallel assembly of chromatography column modules connected in a rigid housing the assembly having one common assembly inlet and one common assembly outlet each column module comprising a bed space filled with chromatography medium and each column module comprises integrated fluid conduits which when the column module is connected with other column modules in the rigid housing are adapted to connect the bed space of the column module with the assembly inlet and the assembly outlet wherein the total length and/or volume of the fluid conduit from the assembly inlet to one bed space together with the length and/or volume of the fluid conduit from the same bed space to the assembly outlet is substantially the same for all bed spaces and modules installed in the parallel assembly.

Parallel assembly of chromatography column modules

A parallel assembly () of chromatography column modules () connected in a rigid housing (), the assembly having one common assembly inlet () and one common assembly outlet (), each column module comprising a bed space () filled with chromatography medium and each column module comprises integrated fluid conduits which when the column module is connected with other column modules in the rigid housing are adapted to connect the bed space () of the column module with the assembly inlet () and the assembly outlet (), wherein the total length and/or volume of the fluid conduit from the assembly inlet to one bed space together with the length and/or volume of the fluid conduit from the same bed space to the assembly outlet is substantially the same for all bed spaces and modules installed in the parallel assembly.

Disclosed is a chromatography column cylinder () formed from a polymer composite comprising an outer layer () and inner layer () intended to be in direct contact with the intended contents of the cylinder in a volume (), wherein the outer layer supports the inner layer, for example when there is negative pressure in the volume (). In one embodiment, one of said layers is molded directly onto a surface of the other layer such that there is no gap between the two layers. Disclosed also is a method for forming a chromatography column cylinder.

Layered chromatography column cylinder

A method for performing maintenance on a chromatography column () comprising the steps of:

Method for performing maintenance on a chromatography column

In a chromatography column, at least one plastic retaining mesh is attached to a distributor plate using a fixture element comprising an elongated edge that penetrates into the plastic mesh to ensure sealing and to prevent radial movement of the plastic mesh.

Growing community of inventors

Uppsala, Sweden

Daniel Salomonsson