Rutgers, the State University of New Jersey

University of Medicine and Dentistry of New Jersey

Taxis Pharmaceuticals, Inc.

Daniel S Pilch

Edmond Joseph LaVoie

Ajit S Parhi

Malvika Kaul

Yongzheng Zhang

Joseph E Rice

Ajit K Parhi

Gifty A Blankson

Edmond J Lavoie

Ajit Parhi

Liping Wang

Suzanne G Rzuczek

Xiao Chen

Edgar Ferrer-González

The invention provides a compound of formula I: or a salt thereof, wherein Y, Z, L, and W have any of the values described in the specification, as well as compositions comprising a compound of formula I or a salt thereof. The compounds are useful as tools for visualizing FtsZ and monitoring cell division in a broad range of Gram-positive and Gram-negative bacterial pathogens of acute clinical importance and for identifying new FtsZ inhibitors.

Fluorescent probes for the visualization of FtsZ in gram-positive and gram-negative bacterial pathogens

The invention provides synthetic methods and synthetic intermediates that are useful for preparing the antibacterial compound: 

Antimicrobial agents

Disclosed herein are compounds of formula I: and salts thereof. Also disclosed are compositions comprising compounds of formula I and methods using compounds of formula I. 

Bacterial efflux pump inhibitors

The invention provides compounds of formula (I): wherein R-R, n, and W have any of the values defined in the specification, and salts thereof. The compounds have good solubility and are useful for treating bacterial infections.

Disclosed herein are compounds of formula I: and salts thereof. Also disclosed are compositions comprising of compounds of formula I and methods using compounds of formula I.

The invention provides methods of treating a bacterial infection in a mammal comprising administering to the mammal a substituted bicyclic heteroaromatic ring compound of formula I: wherein two of Xto Xare N and the remaining of Xto Xare CH; or a pharmaceutically acceptable salt thereof, as well as novel compounds of formula I and salts thereof and pharmaceutical compositions comprising a compound of formula I or a pharmaceutically acceptable salt thereof. 

The invention provides compounds of formula (I): wherein R-Rand W have any of the values defined in the specification, and salts thereof. The compounds have good solubility and are useful for treating bacterial infections.

The invention provides a compound of formula I: or a salt or prodrug thereof, wherein Y, W, Z, Z, Z, Z, Z, and R-Rhave any of the values described in the specification, as well as compositions comprising a compound of formula I. The compounds are useful as antibacterial agents.

The invention provides a compound of formula I: or a salt thereof, wherein R-Rand X and Y have any of the values described in the specification, as well as compositions comprising a compound of formula I. The compounds are useful as antibacterial agents. 

The invention provides a compound of formula (I): or a salt or prodrug thereof, wherein R, R-R, R, R-R, W, and A have any of the values described in the specification, as well as compositions comprising a compound of formula (I). The compounds are useful as antibacterial agents. 

The invention provides compounds of formula (I) wherein u, d, v, m, n, R, W, X, Y, and Z have any values defined herein, as well as salts thereof. The compounds have activity as anti-proliferative agents. 

Therapeutic compounds

The present invention provides compounds of formula I: formula (I) wherein X-Xand R-Rhave any of the values defined in the specification, as well as salts and prodrugs thereof, which inhibit major molecular mechanisms associated with bacterial cell division and proliferation so as to be useful for the treatment and/or prevention of bacterial infections. The invention also provides compositions comprising these compounds as well as methods for using these compounds to inhibit bacterial cell division and proliferation and to treat bacterial infections. 

Growing community of inventors

New Brunswick, NJ, United States of America

Daniel S Pilch