Eastman-kodak Company

Other

Johnson & Johnson Clinical Diagnostics, Inc.

Clinical Diagnostic Systems, Inc.

Wardan, L.l.c.

Daniel S Daniel

John L Toner

James R Schaeffer

David A Hilborn

Mary H Delton

Calvin Roman Messing

Ward Beryl Bowen, Jr

Ignazio S Ponticello

Richard C Sutton

Harold C Warren

Susan J Danielson

Arthur H Herz

Thomas R Kissel

Bruce E Babb

Richard L Detwiler

Andrew M Kirsch

Jack C Chang

Karen L Warren

Vincent W Bakos

Charles J Battaglia

Susan M Geer

James E Love, Jr

A method for accelerating the process of removing ethanol from the blood through the use of certain additives that accelerate the metabolic oxidation of ethanol, and others which in addition act as catalysts or 'pseudo' enzymes for the oxidation. These additives include multivalent transition metal ions, as well as complexes thereof, and NADwhich enhance the oxidation reaction. The method described can act as a sobriety inducer and/or as an effective palliative for the unpleasant effects of overuse of ethanol.

Method for the accelerated in vivo removal of ethanol

A composition for accelerating the disposal of ethanol from bodily fluid. Certain additives can accelerate the metabolic oxidation of ethanol, and others in addition act as catalysts or &ldquo;pseudo&rdquo; enzymes for the oxidation. Additives include the oxidant Nicotinamide Adenine Dinucleotide and a variety of other additives such as transition metal ions and complexes thereof which favor the oxidation reaction. The compositions described can act as a sobriety inducer and/or as an effective palliative for the unpleasant effects of overuse of ethanol.

Method and composition for the accelerated in vivo removal of ethanol

Improved dry-operative ion-selective electrodes and their use are described. The dry-operative ion-selective electrodes include an internal reference electrode comprising a water-soluble salt dispersed in a polymer binder consisting essentially of a monomer having at least one carboxyl group and a hydrophobic monomer. The polymer provides reduced brittleness, good interlayer adhesion and high salt tolerance.

Polymeric compositions for ion-selective electrodes

A dry immunoassay analytical element, for assaying a ligand, comprising in the following order:

Immunoassay elements comprising polymers containing vandium IV (V+4) ions

A dry immunoassay analytical element, for assaying a ligand, comprising a support bearing:

Immunoassay analytical elements containing vanadium IV(V.sup.+4)ions

A method and multilayer analytical element for the determination of catechol and catechol generating substances such as salicylate is described. A series of enzymatic conversions involving tyrosinase is used to convert catechol to o-quinone and the latter to convert a leuco dye to a colored dye.

Method and element for assay of catechol and catechol generating

A multilayer analytical element for quantitatively assaying ethanol comprising a tetrazolium salt, alcohol dehydrogenase, NAD.sup.+, and an electron transfer agent characterized in that the layer comprising the electron transfer agent also includes a polymer having recurring negatively charged groups and the NAD.sup.+ is in a different layer is disclosed.

Ethanol analytical element

Sodium ion selective compositions which comprise an ion carrier, a compound capable of solvating the ion carrier, and a supporting matrix are disclosed. The ion carriers of this invention are hemispherand compounds represented by the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, and R.sup.4 are independently hydrogen, alkyl, alkenyl, cycloalkyl, aryl or a heterocyclic group and R represents Z-decyl, Z-octyl, 3-octyl, and cyclohexyl methyl.

Hemispherand ionophores having increased lipophilicity

Ion-selective compositions which comprise an ion carrier, a compound capable of solvating the ion carrier, and a supporting matrix are disclosed. The ion carrier according to the invention is a lipophilic hemispherand compound. These compositions are particularly useful in ion-selective electrodes. Such an electrode is capable of selectively transporting a first ion in preference to a second ion. Particularly useful hemispherands have a .DELTA.G of complexation with the first ion which is at least 0.3 Kcal/mole greater than the .DELTA.G of complexation with the second ion. Dry-operative electrodes using these ion-selective compositions as membranes are also disclosed.

Hemispherands in ion-selective compositions

An analytical composition, electrode and method are useful for the detection of lithium ions in an aqueous liquid. The lithium ion-selective composition comprises a lipophilic group-substituted 1,10-phenanthroline, a compound capable of solvating the phenanthroline, and a supporting matrix. This composition can be used in a lithium ion-selective electrode as a lithium ion-selective membrane. The electrode can also comprise an internal reference electrode.

Lithium ion-selective compositions, electrodes and a method of use

A particular class of triarylmethane leuco dyes are useful in analytical compositions, elements and methods. These leuco dyes are triarylmethane compounds having an aromatic heterocyclic moiety attached to the central methane carbon and which, upon interaction with hydrogen peroxide, provide dyes having a maximum absorption at a wavelength equal to or greater than about 600 nm. Particularly useful leuco dyes have the structure: ##STR1## wherein R is a 5- to 15-membered aromatic heterocyclic moiety; and R' and R' are independently open chain or cyclic amines. These compounds are useful for providing detectable dyes in compositions and elements useful for detection of hydrogen peroxide or other analytes which react to produce hydrogen peroxide in aqueous liquids, e.g. biological fluids.

Compositions and elements containing triarylmethane leuco dyes and

Potassium ion-selective compositions which comprise valinomycin and a particular carrier solvent capable of solvating valinomycin are disclosed. The carrier solvent is a dicarboxylic acid diester having at least 25 carbon atoms, a viscosity of less than about 120 centipoise at 20.degree. C. and a boiling point greater than about 170.degree. C. at 5 mm pressure. A preferred carrier solvent is diisodecyl phthalate. Membranes prepared from these compositions preferably have a glass transition temperature greater than about -50.degree. C. These membranes are particularly useful in dry-operative potassium ion-selective electrodes which are capable of selectively determining potassium ions in preference to other ions.

Potassium ion-selective compositions and electrodes containing same

Ion-selective compositions which comprise an ion carrier, a compound capable of solvating the ion carrier, and a supporting matrix are disclosed. The ion carrier useful in this invention is a hemispherand compound represented by the structure: ##STR1## wherein X.sub.1, X.sub.2, X.sub.3 and X.sub.4 are independently alkyl or alkenyl, or any one of X.sub.1, X.sub.2, X.sub.3 and X.sub.4 is taken with one of the others of X.sub.1, X.sub.2, X.sub.3 and X.sub.4 to form an alkylene group or an alkylene group interrupted with hetero atoms; and R represents the atoms necessary to complete a macrocyclic ring structure having from 16 to 19 atoms in the backbone of the ring structure, with the proviso that R contains (a) at least one coordinating site for sodium ions and (b) at least two alkylene groups as part of the ring structure. These compounds and the compositions containing same are particularly useful in ion-selective electrodes. Such an electrode is capable of selectively transporting sodium ion in preference to other cations. Dry-operative electrodes using these ion-selective compositions as membranes are also disclosed.

Sodium-selective compositions and electrodes containing same

Ion-selective compositions which comprise an ionophore, a compound capable of solvating the ionophore and a supporting matrix are disclosed. The ionophores useful in these compositions are certain crown ethers. These ion-selective compositions are particularly useful in ion-selective membranes and electrodes which are capable of selectively transporting a first ion in preference to a second ion. Such compositions, membranes and electrodes are useful for potentiometric measurement of alkali metal ions, e.g. lithium, sodium and potassium, in aqueous solutions, e.g. biological fluids. Dry-operative electrodes using these ion-selective compositions as membranes are also disclosed.

Growing community of inventors

Rochester, NY, United States of America

Daniel S Daniel