Biosense, Inc.

Other

Biosene, Inc.

Bioscience, Inc.

Daniel Reisfeld

Margarita Osadchy

Armin Schwartzman

The property of cardiac tissue at a local site, a plurality of sites of in a region of a heart may be characterized based on local electrograms measured at the local site, at a plurality of sites or in the region, respectively. The property may be characterized by normalizing the local electrogram, extracting a feature vector from the normalized electrogram, and classifying the tissue property based on the feature vector. The method of may further include computing a map of the tissue property and treating the tissue based on the resultant map. Apparatus to characterize the property includes a catheter and a processor to normalize the local electrogram, extract the feature vector from the electrogram and classify the tissue based on the feature vector.

Method and apparatus for characterizing cardiac tissue from local electrograms

A method is provided for generating a three-dimensional reconstruction of a portion of a surface of an organ, and, in particular, a portion of the surface of a chamber of the heart. The reconstruction is generated from location data of a plurality of acquisition points on the organ surface. The method comprises computing a two-dimensional reference plane based on the location data. A function that describes the surface is computed, wherein each point on the surface may be described as a function of the reference plane. The function is then bounded to a constrained region. Tessellation of the function facilitates computer display of the reconstruction. If the location data is accompanied by physiologic property data characteristic of the tissue, the method may be used to generate a reconstruction of the tissue property as a function of the tissue geometry.

Area of interest reconstruction for surface of an organ using location data

A method for vascular reconstruction comprises the steps of advancing a catheter having a position sensor into the vessel, acquiring position information from the sensor at a plurality of points in the vessel, calculating a center-line of the vessel based on said position information, and calculating the inner surface of the vessel. The method of the invention preferably further comprises displaying the vessel reconstruction. The invention is also directed to apparatus for reconstructing vessels which comprises a catheter having a position sensor contained therein, means for acquiring position information from said sensor at a plurality of points in said vessel, means for calculating a centerline of the vessel based on said position information, and means for calculating the inner surface of the vessel.

Vascular reconstruction

A method of reconstructing a map of a volume, including determining coordinates of a plurality of locations on a surface of the volume having a configuration, generating a grid of points defining a reconstruction surface in 3D space in proximity to the determined locations, for each of the points on the grid, defining a respective vector, dependent on a displacement between one or more of the points on the grid and one or more of the locations, and adjusting the reconstruction surface by moving substantially each of the points on the grid responsive to the respective vector, so that the reconstruction surface is deformed to resemble the configuration of the surface.

Three-dimensional reconstruction of intrabody organs

A condition, such as an electrical property, of a chamber of a heart is surveyed with a catheter having a condition sensor at its distal tip. A method for surveying the chamber includes the steps of acquiring a first image of the chamber containing topographical information, advancing the distal tip of the catheter into the chamber, acquiring a second image including a representation of the catheter distal tip in the chamber, displaying a superposition of the topographical information extracted from the first image with the second image to generate a displayed superimposed image, acquiring condition information at a point on the chamber displayed on the superimposed image on or near the topographical information, and acquiring condition information at one or more additional points sufficient in number and spacing to permit the generation of a survey map of the condition in the chamber. The method preferably further includes marking the display of the superimposed image to identify the points on the chamber at which the condition information was acquired.

Method and apparatus for intracardially surveying a condition of a chamber of a heart

A method for intracardially mapping a condition such as an electrical or mechanical property of a chamber of a heart uses a catheter having a distal tip and at least one condition sensor contained therein or proximate thereto. The at least one sensor is capable of sensing condition information in the chamber and provides the three-dimensional position of the catheter tip in a positional frame of reference. The method includes the steps of acquiring first and second images of the chamber. The images are acquired from different projections and contain topological information of the chamber. The chamber images are registered with the positional frame of reference. The catheter distal tip is advanced into the catheter and is navigated to acquisition points under the guidance of topological information contained in or derived from the images. Condition and position information are acquired at each of the acquisition points, the points being sufficient in number and spacing to permit the generation of a map of the condition in the chamber. The topological information used to guide the navigation of the catheter is preferably a three-dimensional reconstruction of the chamber derived from the topological information contained in the images.

Method and apparatus for mapping a chamber of a heart

A method of diagnosing an abnormal condition in a biological structure, such as the heart, including the steps of measuring a physiological response at at least three sampled points on a surface of the biological structure, calculating a vector function related to the response, displaying a representation of the vector function, and inferring the abnormal condition from the representation. The present invention is particularly useful for diagnosing cardiac arrhythmias, in which case the physiological response is a voltage, from which is inferred a local activation time and the vector function is a gradient of the local activation time, specifically, a conduction velocity.

Growing community of inventors

Haifa, Israel

Daniel Reisfeld