Rhone-poulenc Industries

Other

Rhone-poulenc Rorer S.a.

Institute Malgache De Recherches Appliquees

Daniel Reisdorf

Daniel Farge

Gerard Ponsinet

Alain Jossin

Jean Leboul

Jean Provost

Philippe Rasoanaivo

Albert Rakoto Ratsimamanga

Suzanne Rakoto Ratsimamanga

Jean-Bernard Ducep

Claude James

Michel Evers

Yves Ribeill

Norbert Dereu

Francoise Soler

Jean-Christophe Gueguen

Jean Bernard Ducep

Christele Poujade

Romaine Bouboutou

The present invention relates to mixtures which can be isolated from grains of Eugenis Jambolana Lamarck, the preparation of such mixtures, the medicaments containing said mixtures or constituents of said mixtures, and the use of these mixtures and constituents for the preparation of a medicament.

Sodium oxamate for the treatment of diabetic conditions

Mixtures derived from grains of Eugenia Jambolana Lamarck preparation and use of said mixtures and some of their constituents as medicaments

Mixtures derived from grains of eugenia jambolana lamarck, preparation

The present invention relates to new lupane dervivatives of the general formula: ##STR1## to their salts, to their preparation and to the pharmaceutical compositions which contain them.

Lupane derivatives, their preparation and the pharmaceutical

Isoquinoline derivatives of the formula ##STR1## wherein the symbol A.sub.1 represents an isoquinol-8-yl, 3-methylisoquinol-8-yl, 3-hydroxymethylisoquinol-5-yl, 3-carboxymethylisoquinol-5-yl, quinol-5-yl, thienopyridyl, benzimidazolyl, thienyl or thiazolyl radical, a 4-(or 5-)carboxyalkylthiazol-2-yl radical in which the alkyl moiety is linear or branched and contains 1 to 4 carbon atoms, or a 1,3,4-thiadiazol-2-yl, pyrazolyl, imidazolyl, pyrimidinyl, pyridazinyl or pyrazinyl radical, monocyclic heterocyclic rings within the definition of A.sub.1 being optionally substituted by a linear or branched alkyl radical containing 1 to 4 carbon atoms, in the (S) or (R,S) form or mixtures thereof, and salts thereof possess useful pharmocological properties, in particular antiviral activity.

Thiazolo[3,4-b]isoquinolines

Isoquinoline derivatives of the formula: ##STR1## wherein R.sub.1 represents alkyl of 1 through 8 carbon atoms, and n represents 1 or 2, are new compounds possessing useful pharmacological properties. They are particularly valuable as analgesic, anti-inflammatory, antipyretic or antiviral agents.

Antiviral isoquinoline derivatives

Rhinoviral complaints are treated by administering a product of the general formula: ##STR1## in the (S) form, in which formula A is pyrid-3-yl which is unsubstituted or substituted in the 2-position by chlorine, fluorine or methoxy, isoquinol-5-yl, or 3-methyl-isoquinol-5-yl, or one of its pharmaceutically acceptable salts.

Method for treating rhinoviral complaints

Indole derivatives of the formula: ##STR1## wherein Z represents hydrogen, alkyl of 1 through 10 carbon atoms, or alkoxyalkyl of the formula --(CH.sub.2).sub.n --OR in which R represents alkyl of 1 through 8 carbon atoms and n represents 1 or 2, and their non-toxic pharmaceutically acceptable acid addition salts, are new compunds possessing useful pharmacological properties. They are particularly valuable as analgesic agents; some of them are also useful as anti-inflammatory and antipyretic agents.

Indole derivatives

Isoquinoline derivatives of the formula: ##STR1## wherein R represents alkyl of 1 through 8 carbon atoms, and n represents 1 or 2, and their non-toxic pharmaceutically acceptable acid addition salts, are new compounds possessing useful pharmacological properties. They are particularly valuable as analgesic agents; some of them are also useful as anti-inflammatory and antipyretic agents.

Isoquinoline derivatives

Thienopyridine derivatives of the formula: ##STR1## wherein the symbol A represents pyrid-3-yl, isoquinol-5-yl, or a 3-alkylisoquinol-5-yl group in which the alkyl radical is of 1 through 10 carbon atoms, and one of the symbols X and Y represents a single bond and the other represents the vinylene radical, are new compounds possessing useful pharmacological properties. They are particularly useful as anti-viral agents and, in certain cases, as analgesics, anti-inflammatory agents and anti-pyretics.

Thiazolothienopyridines and anti-viral compositions thereof

Daunorubicin derivatives of the formula: ##STR1## wherein R.sub.1 represents a group of the formula: ##STR2## in which (i) X.sub.1 and X.sub.2 both represent oxygen or both represent sulphur and the symbols R.sub.3 each represent alkyl of 1 through 4 carbon atoms, phenyl or phenyl substituted in the para-position by methyl, methoxy or methylthio, or together form an alkylene radical of 2 through 4 carbon atoms, or (ii) one of X.sub.1 and X.sub.2 represents oxygen and the other represents sulphur and the symbols R.sub.3 together form an alkylene radical of 2 through 4 carbon atoms, and R.sub.4 represents hydrogen, alkyl of 1 through 4 carbon atoms or phenyl, and R.sub.2 represents hydrogen or trifluoroacetyl, are new compounds possessing anti-tumour properties.

Daunorubicin derivatives

Isoquinoline derivatives of the formula: ##STR1## wherein A represents pyrid-3-yl, isoquinol-5-yl or a 3-alkylisoquinol-5-yl radical in which the alkyl moiety contains 1 to 10 carbon atoms, are new compounds, possessing useful pharmacological properties. They are particularly valuable as analgesic, anti-inflammatory and antipyretic agents.

Daunorubicin derivatives of the general formula: ##STR1## wherein each of the symbols R represents a hydrogen atom or a methyl or ethyl radical, are new therapeutically useful compounds possessing anti-tumoral properties.

Isoquinoline derivatives of the formula: wherein R represents alkyl of 1 through 10 carbon atoms, which are new compounds, possess pharmacological properties and are particularly active as anti-inflammatory, analgesic and antipyretic agents.

Isoquinoline derivatives and pharmaceutical compositions containing them

Compounds of the formula: ##STR1## wherein A represents a heterocyclic radical selected from 3-pyridyl, 4-pyridyl, 5-isoquinolyl and 5-isoquinolyl substituted in the 3-position by an alkyl radical containing 1 to 10 carbon atoms, are new compounds possessing pharmacological properties, in particular analgesic, antipyretic and anti-inflammatory properties.

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Thiais, France

Daniel Reisdorf