Pierre Fabre Dermo-cosmetique

Université Paul Sabatier (toulouse Iii)

Université Paris-Sud 11

Centre Hospitalier Universitaire De Toulouse

Daniel Redoules

Sylvie Daunes-Marion

Jean-Jacques Perie

Roger Tarroux

Marie-Françoise Aries

Stéphane Poigny

Pascal Bordat

Jean-Hilaire Saurat

Nathalie Castex-Rizzi

Corinne Dechelette

Hélène Duplan

Gwendal Josse

Marie-Florence Galliano

Alexandre Delalleau

Anne-Marie Schmitt-Milas

Sandrine Bessou-Touya

Didier Fournier

Pierre Gros

Helene Duplan

Marie-Francoise Aries

Emmanuel Questel

Audrey Ruffien-Ciszak

Maurice Comtat

Christiane Casas

This invention relates to a topical, cosmetic or dermatological composition, comprising a 1,3 diglyceride having the general formula (I), in which the radicals R1 and R2 represent, independently of one another, a C13 to C40 saturated and linear alkyl radical, and at least one cosmetic or dermatological excipient for a topical application on the skin. This invention also relates to such a composition, or a 1,3 diglyceride having the formula (I), for its use in protecting the skin, in countering the weakening of the skin barrier and in preventing or reducing the penetration of exogenous molecules into the skin following a weakening of the skin barrier.

Use of 1,3 diglyceride in a topical composition for countering the weakening of the skin barrier

The present invention concerns a combination of a retinoid and a diol and polyunsaturated fatty acid ester, a dermatological or dermocosmetic composition containing such a combination and use of same in the treatment of acne and the prevention of retentional lesions. The present invention also concerns a retinoid, optionally in combination with a diol and polyunsaturated fatty acid ester, for use in the prevention of retentional lesions.

Combination of a retinoid and a diol and polyunsaturated fatty acid ester

The invention relates to a ternary lipid association of &#x3b2;-sitosterol, isocetyl stearoyl stearate and glyceryl tri-2-ethylhexanoate, wherein the &#x3b2;-sitosterol content of said association is between 0.1% and 5 wt. %.

Cosmetic composition comprising a ternary lipid association for controlling dryness of the skin

The present invention relates to L-glutamate-derived compounds of general formula (I) in which the R radical is a linear or branched Cto Calkyl group, .&#x2014;or the benzyl radical, .&#x2014;or the phenethyl radical, for topical use as a medicament (or as a dermatological active ingredient) intended for the treatment and/or prevention of inflammatory dermatoses.

Glutamate derivatives for topical use as immunomodulatory active ingredient

The present invention relates to Formula (I), wherein&#x2014;if X=NH, each of R, R, R, Rrepresents a hydrogen atom; if X=N, the core is aromatic, and R, Rand Rrepresent hydrogen atoms, and R1=H, halogen, aryl, heteroaryl, alkenyl or acetylenyl; or R, R, R, Rare defined such that R1 or R2 or R3 or R4 represents a methyl group, and the three other radicals represent a hydrogen atom. 

Lipogenesis inhibitor compounds

The present invention relates to compounds of the following formula (I): where n is an integer between 1 and 15, m is 0, 1, 2 or 3, and R is the hydrocarbon chain of a polyunsaturated fatty acid selected from among omega 3 and omega 6, as well as to pharmaceutical or cosmetic compositions containing same, to a method for preparing and using same, in particular for treating acne and seborrhoeic dermatitis.

Polyunsaturated fatty acid and diol ester as an anti-acne agent

The invention concerns a bioprecursor of formula (I), wherein Aand Arepresent independently of each other a radical derived from a molecule capable of being used in dermatology or in cosmetology; X and Y represent independently of each other a hydrogen atom, a hydroxy group or a C&#x2013;Calkyl group; and n represents an integer between 0 and 10 

Bioprecursors for percutaneous application

The present invention relates to a ternary glucosyl complex which is a bioprecursor of at least one retinoic active ingredient for percutaneous application, having formula (I), wherein E represents a linear hydrocarbon spacer group that is branched or cyclized and has an aliphatic or aromatic content capable of containing one or several heteroatoms of oxygen and carrying one or several carbonyl groups; A represents a radical of a molecule of said retinoic active ingredient linked to the spacer group by a carboxylate function and n&equals;1 or 2.

Bioprecursors of a retinoic derivative and pharmaceutical and/or cosmetic compositions

The invention concerns a composition capable of being hydrolyzed by a cutaneous enzyme, glucocerebrosidase. The active precursor is advantageously a gluco-conjugate derived from phenol whereof the two &agr; carbons are free. The invention also concerns the use of such compositions against light-induced skin ageing or for making a medicine for treating certain skin diseases. The invention further concerns novel glucosylated compounds.

Composition containing a precursor capable of being hydrolysed by glucocerebrosidase

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Toulouse, France

Daniel Redoules