Consejo Superior De Investigaciones Cientificas

Daniel Ramos Vega

Francisco Javier Tamayo De Miguel

Valerio Pini

Priscila Monteiro Kosaka

Jose Jaime Ruz Martinez

Montserrat Calleja Gómez

Montserrat Calleja Goméz

Maria Ujue Gonzalez Sagardoy

Alberto Martín Pérez

Oscar Malvar Vidal

Óscar Malvar Vidal

Mario Encinar Del Pozo

Montserrat Calleja GÓMEZ

Alberto MARTÍN PÉREZ

ÓScar Malvar Vidal

The method uses a suspended resonating microcapillary device, and obtains simultaneously three parameters of the analytes: mass, size and refractive index, enabling the unequivocal classification of the analytes flowing in real time, based on the resonance frequency displacement and the change in reflectivity of the transparent microcapillary. The method comprises the stages of: the obtaining of a measurement of the reflectivity of the sample analytes within the capillary at each moment in time; the obtaining of a mechanical reference signal (T) of the change in resonance frequency of the microcapillary caused by the sample analytes over time; and the detection of the passage of the particle through an area of the capillary, and the obtaining of the points of passage of the ends of the analytes through the centre of the illuminated area, obtaining an optical signal ΔT.

Method for hydrodynamics-assisted multi-parameter analyte spectrometry

An analysis system includes a reflective substrate; a hollow elongate structure with two ends; two polymer supports coupled to the ends and joined to the substrate; a piezoelectric device coupled to the substrate and designed to produce vibrations in the elongate structure; a laser for emitting a beam; a beam splitter; a photodetector; an amplification module; and a processor. The laser beam passes through the cavity and is absorbed by the photodetector, which generates a signal that is transmitted to the amplification module. The amplification module separates the signal into a modulated component and an unmodulated component. The signal is transmitted to the processor to obtain the resonance frequency and reflectance and to provide the piezoelectric device with an excitation signal at the resonance frequency.

Mechano-optical analysis system, method for producing same, use for identifying and classifying cell populations and mechano-optical analysis method

The present invention relates to a system for biodetection applications comprising two basic elements, a substrate with a functionalized surface and a nanoparticle, the system being capable of enhancing the plasmonic effect of the nanoparticle. The invention also relates to a biosensor incorporating such system, in addition to the method for detecting and quantifying a target analyte selected in a sample using such system. Finally, the invention relates to a device which can detect the enhanced optoplasmonic effect of the nanoparticles by means of the system of the invention or by combining the detection of such optoplasmonic effect with the analysis of the changes in the mechanical characteristics in the substrate.

System for biodetection applications

The invention relates to a spectrophotometer, especially a spectrophotometer that can carry out simultaneous analysis at different points on the same sample (), with a high spatial resolution and without requiring a mechanical system for physical scanning along the sample. This is obtained by the provision of means for processing the light received by the photodetectors (), said processing means having a correlation wherein each of the photodetectors () corresponds to a spatial point on the sample (). In the case of dark field applications, the present invention ensures the standardization of the data using the same measure.

Spectrophotometer

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Madrid, Spain

Daniel Ramos Vega