Biocept, Inc.

Iscience Interventional Corporation

Avendo Imaging Systems

Daniel Rachlin

Stanley R Conston

Venkata Vishnu Gurukula

Jacques Van Dam

An endoscope with flexible cable is described having a first set of means to facilitate travel of an imaging capsule down the esophagus, a second set of means to enable proper orientation and optical clarity of the capsule, and a third set of means to enable ease in retrieval of the device. In most embodiments, there is an overlap of these sets of means, the combination of which assures optimal exam effectiveness while maintaining a high degree of patient comfort. The endoscope can target low cost, high volume screening for diseases of the upper digestive tract.

Tethered endoscope

A device () used with high frequency ultrasound provides a replaceable barrier between the ultrasound transducer and the tissues being imaged. The device () provides an acoustic pathway of minimal effect on the ultrasound signals, and furthermore provides for a safety barrier between a mechanical scanner and the tissues being imaged. The configuration of the device () allows it to function as a standoff for the ultrasound transducer to place the focus of the ultrasound beam at the desired depth of tissue for imaging. In addition, the device () may be sterilized and replaced as needed, providing sterile tissue contact surfaces. The device () has additional features, which are especially advantageous for diagnosis and surgery of the eye.

Ultrasound interfacing device for tissue imaging

A reflective substrate is used to amplify the photon signal captured from overlying analyte domains containing photon emitters. The reflective substrate provides substantial desired signal amplification of the photon emissions from each domain via interference effects induced in the incident excitation and/or emission energies. A dielectric is interposed between the domains and the reflective surface, which has a thickness such that substantial destructive interference occurs with respect to emission photons or excitation photons or both at the attachment surface. When analyte domains have a three-dimensional structure such that a significant fraction of their volume extends at least &#xbc; wavelength above the attachment surface provided by the dielectric, substantial constructive signal amplification can take place of signals generated within the analyte domains. Destructive interference relating to emissions arising from the plane of attachment surface yields significant reduction in spurious background emissions.

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San Jose, CA, United States of America

Daniel Rachlin