Human Genome Sciences, Inc.

Takeda Gmbh

Avalon Pharmaceuticals, Inc.

Human Gene Sciences

Daniel R Soppet

Steven M Ruben

Craig A Rosen

Yi Li

Reinhard Ebner

Paul E Young

Henrik S Olsen

Yanggu Shi

Kimberly A Florence

Paul A Moore

Jian Ni

Gregory A Endress

Laurie A Brewer

David W LaFleur

George Komatsoulis

Roxanne Duan

Ying-Fei Wei

Kenneth C Carter

Patrick J Dillon

Ann MeeJin Ferrie

John M Greene

Guo-Liang Yu

Haodong Li

Carrie L Fischer

Michael Mucenski

Jing-Shan Hu

Ping Feng

Charles E Birse

Kevin P Baker

Mark D Adams

Shuji Hinuma

Ryo Fujii

David William Lafleur

Ping Fan

Ping Wei

Daniel P Bednarik

Hla Kyaw

Zhizhen Zeng

Michele Fiscella

Reiner L Gentz

Gregg A Hastings

Stanislaw Pikul

Charles Florence

Fouad Janat

Human G-protein parathyroid hormone (PTH) receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the PTH receptor receptor polypeptides. Also disclosed are diagnostic methods for detecting a mutation in the PTH receptor receptor nucleic acid sequences and detecting a level of the soluble form of the receptors in a sample derived from a host. Disclosed embodiments of the invention also include antibodies that bind Human G-Protein parathyroid hormone (PTH) receptor polypeptides and methods for making and using such antibodies.

Method of producing an antibody to G-protein parathyroid hormone receptor HLTDG74

The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

Antibodies to HBIMF63 polypeptide

Antibodies to HHPEN62 polypeptide

Human colon specific gene polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polynucleotides or polypeptides as a diagnostic marker for colon cancer and as an agent to determine if colon cancer has metastasized. Also disclosed are antibodies specific to the colon specific gene polypeptides which may be used to target cancer cells and be used as part of a colon cancer vaccine. Methods of screening for agonists and antagonists for the polypeptide and therapeutic uses of the antagonists are also disclosed.

Colon specific gene and protein

The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.

Secreted protein HRGDF73

Antibodies against human protein HUVDJ43

Secreted protein HCE3C63

Antibodies to protein HPMBQ91

The present invention discloses Growth Factor HTTER36 polypeptides and polynucleotides encoding such polypeptides. Also disclosed are antibodies and fragments thereof that specifically bind to such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and therapeutic uses of the polypeptides which include stimulating cellular growth and differentiation, bone formation and wound healing. Also disclosed are antagonists against such polypeptide and their use as a therapeutic to treat neoplasia and to prevent the formation of extracellular matrix molecules in the liver and lung. Also disclosed are diagnostic assays for detecting altered levels of the polypeptide of the present invention and mutations in the nucleic acid sequences which encode the polypeptides of the invention.

Antibodies to growth factor HTTER36

The present invention relates to PSGR, a novel prostate specific gene with homology to a G-protein coupled receptor overexpressed in prostate cancer. More specifically, the invention relates to PSGR polynucleotides and the polypeptides encoded by these polynucleotides, and the use of PSGR polynucleotides and polypeptides for detecting disorders of the reproductive system, including disorders of the prostate, particularly the presence of cancer. This invention relates to PSGR polynucleotides and polypeptides as well as vectors, host cells, antibodies directed to PSGR polynucleotides and polypeptides and recombinant and synthetic methods for producing the same. Also provided are methods for diagnosing, treating, preventing, and/or prognosing disorders related to the prostate, including cancer. The invention further relates to screening methods for identifying agonists and antagonists of PSGR polynucleotides and polypeptides of the invention and methods and/or compositions for inhibiting or enhancing the production and/or function of the PSGR polypeptides of the present invention.

Antibodies that bind human prostate specific G-protein receptor HPRAJ70

Secreted protein HBJFE12

Antibodies to secreted protein HCEJQ69

The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. In particular, the present application relates to a novel human protein, Protein HOFNF53. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

Protein HOFNF53

Secreted protein HODAZ50

49 human secreted proteins

Growing community of inventors

Centreville, VA, United States of America

Daniel R Soppet