Boehringer Ingelheim Pharmaceuticals, Inc.

Gyrus Acmi, Inc.

Smith + Nephew

Roivant Sciences Gmbh

Karos Pharmaceuticals, Inc.

Boehringer Ingelheim International Gmbh

Altavant Sciences Gmbh

Kanos Pharmaceuticals, Inc.

Gyrus Acml, Inc.

Gyras Acmi, Inc.

Boehringer Ingelheim Pharma Gmbh & Co Kg

Gyrus Acmi, Inc D/b/a Olympus Surgical Technologies America

Daniel R Goldberg

Neil Moss

Abdelhakim Hammach

Stéphane De Lombaert

Jeffrey Joel Shea

David C Church

Nathaniel M Quinn

Eric Brian Sjogren

Kenneth Albert Brameld

Donghong Amy Gao

Gregory S Konstorum

Ming J Cheng

Zhaoming Xiong

Kevin Cooper Edwards

Roger John Snow

Joel A Willhite

Ahmad Alsaffar

Andrew Scribner

Ming-Hong Hao

Derek Cogan

Stanley Tsai

Ronald A Aungst, Jr

Hidenori Takahashi

Tina Marie Morwick

Matthew Russell Netherton

Jiang-Ping Wu

Anthony S Prokopowicz

Pier Francesco Cirillo

Terence Alfred Kelly

Rene Marc Lemieux

Ronald John Sorcek

Victor Marc Kamhi

Kevin Chungeng Qian

Mark Stephen Ralph

J Andrew Willhite

John R Regan

Daniel Kuzmich

Lifen Wu

Mario G Cardozo

Christopher Ronald Sarko

Usha R Patel

Alan David Swinamer

Xiao-Jun Wang

Alexander Heim-Riether

Craig Andrew Miller

Matt Aaron Tschantz

Gregory Paul Roth

Philip Dean Ramsden

Jonathan Emilian Emeigh

Amy L Davis

Robert D Selliah

Lana Louise Smith Keenan

Pingrong Liu

Asitha Abeywardane

Ingo Andreas Mugge

Fariba Soleymanzadeh

Jonathan Emillian Emeigh

Antonio J Barbosa

Yang Yu

Antonio Jose Del Moral Barbosa, Jr

Yu Yang

Kaka Dey

Kristen Mueller

Pier Francesco

Younggi Choi

Andre White

John Edward Mangette

John E Mangette

Ronald A Aungst

An endoscope sheath comprising: a proximal end; a distal end having a distal end region; a surface extending between and connecting the proximal end and the distal end; and a plurality of positioning devices located along the surface; wherein the sheath is configured to: (1) receive all or a portion of an endoscope having a cylindrical end and (2) provide a conduit for communicating fluid between the proximal end of the sheath and the distal end of the sheath when the endoscope is inserted inside the sheath; and wherein the distal end region of the sheath includes the plurality of positioning devices that secure the cylindrical end of the endoscope against a portion of an inner wall of the surface extending between the proximal end and the distal end so that a fluid barrier is created between the cylindrical end of the endoscope and the inner wall.

Oblong endoscope sheath

Systems, methods and devices for providing orthopedic implant augments are provided which have fastener locking mechanisms. The augments include a surface for mating with an implant component and a surface for interfacing with a patient's bone. The fastener locking mechanisms are aligned such that the augment may be locked in a variety of orientations while maintaining close contact with both an implant and a patient's bone. The alignment of the locking mechanisms provides variability and adjustability to the augment to address a variety of bone anatomies and requirements.

Orthopedic implant augments

The present invention is directed to spirocyclic compounds which are inhibitors of tryptophan hydroxylase (TPH), particularly isoform 1 (TPH1), that are useful in the treatment of diseases or disorders associated with peripheral serotonin including, for example, gastrointestinal, cardiovascular, pulmonary, inflammatory, metabolic, and low bone mass diseases, as well as serotonin syndrome, and cancer.

Spirocyclic compounds as tryptophan hydroxylase inhibitors

The present disclosure is directed to intermediates and salts thereof useful for the preparation of spirocyclic compounds which are inhibitors of tryptophan hydroxylase (TPH), particularly isoform 1 (TPH1). Processes of preparing the intermediates, salts, and TPH inhibitors are also provided.

Processes for preparing TPH1 inhibitors

Disclosed herein is a medical device. The medical device includes two coaxially aligned solenoids and a cannulated armature configured to be received within the two coaxially aligned solenoids.

Disposable debrider with cannulated solenoid

Disclosed herein is a medical device. The medical device includes a blade tube section, a solenoid, and a mechanical arrangement. The blade tube section includes an outer blade tube, an inner blade tube, and a cutting window at a distal end of the blade tube section. The solenoid is offset from a central axis of the blade tube section. The mechanical arrangement is between the inner blade tube and the solenoid.

Methods of reciprocation in a surgical shaver

An endoscope sheath configured to receive a portion of an endoscope can include a tubular member and a positioning device located on the tubular member. The positioning device can include a crimp that is configured to prevent distal movement of a portion of the endoscope relative to the tubular member.

Disclosed herein is a medical device. The medical device includes a blade tube section, a motor, and a mechanical arrangement. The blade tube section includes an outer blade tube, inner blade tube, and a cutting window at a distal end of the blade tube section. The motor is offset from a central axis of the blade tube section. The mechanical arrangement is between the inner blade tube and the motor.

Disclosed herein is a medical device. The medical device includes a blade tube section, a motor, and a cotch yoke or slotted link mechanism. The blade tube section includes an outer blade tube, an inner blade tube, and a cutting window at a distal end of the blade tube section. The motor is spaced from the blade tube section. The scotch yoke or slotted link mechanism is between the inner blade tube and the motor.

Disclosed herein is a medical device. The medical device includes a blade tube section, a motor, and a lever arm. The blade tube section includes an outer blade tube, an inner blade tube, and a cutting window at a distal end of the blade tube section. The motor is spaced from the blade tube section. The lever arm is between the inner blade tube and the motor.

Systems, devices and methods for providing orthopedic augments having recessed pockets that receive a fixation material. The orthopedic augments include an outer surface that interfaces with a patient's tissue or bone, an inner surface that interfaces with an implant and having a recessed pocket configured to receive a fixation material, a rim around at least a portion of the recessed pocket, and a port in the rim, wherein the recessed pocket extends along the inner surface in at least a lateral direction from the port.

Orthopedic augments having recessed pockets

A system comprising: (a) a sheath configured to receive all or a portion of an endoscope; (b) an irrigation line connecting the sheath to an irrigation source; (c) a suction line connecting the sheath to a suction source; and (d) a control module located between the sheath, and the irrigation source and the suction source and controls flow of irrigation fluid from the irrigation source to the sheath and movement of suction between the suction source and the sheath; wherein the irrigation source is connected to a resilient reservoir that is located within the control module and movement of the control module compresses the resilient reservoir moving irrigation fluid from the resilient reservoir to the sheath so that the irrigation fluid assists in cleaning the endoscope, and wherein the control module includes a valve and compression of the resilient reservoir initiates movement of the valve so that the valve opens and suction from the suction line is applied to the sheath.

Endoscope system including a resilient reservoir

The present invention relates to processes for the preparation of (R)-1-(5-chloro-[1,1'-biphenyl]-2-yl)-2,2,2-trifluoroethanol, 1-(5-chloro-[1,1&#x2032;-biphenyl]-2-yl)-2,2,2-trifluoroethanone, and intermediates thereof, which are useful in the preparation of inhibitors of TPH1 for the treatment of, for example, gastrointestinal, cardiovascular, pulmonary, inflammatory, metabolic, low bone mass diseases, serotonin syndrome, and cancer.

Processes for preparing (R)-1-(5-chloro-[1,1&#x2033;-biphenyl] -2-yl)-2,2,2-trifluoroethanol and 1-(5-chloro-[1,1&#x2033;-biphenyl]-2-yl)-2,2,2-trifluoroethanone

Growing community of inventors

Redding, CT, United States of America

Daniel R Goldberg