Centre National De La Recherche Scientifique

Lesaffre Et Compagnie

Bio-Rad Innovations

Centre Hospitalier Régional Universitaire De Lille

Université Lille 2 - Droit Et Santé

Université D'auvergne Clermont 1

Centre Hospitalier Universitaire De Lille

Université Sciences Technologies Lille

Centre Hospitalier Regional Universitaire (Chru)

Université Du Droit Et De La Santé Lille 2

Bio-Rad Europe Gmbh

Université De Lille 2 Droit Et Santé

Université De Droit Et De La Santé De Lille 2

Institut National De Recherche En Sciences Et Technologies Pour L'environnement Et L'agriculture

Centre Hospitalier Régional Et Universitaire De Lille

Daniel Poulain

Boualem Sendid

Georges Pignede

Jean-Luc Simon

Pascal Vandekerckove

Arlette Darfeuille-Michaud

Sebastien Damiens

Pierre-André Trinel

Thierry Jouault

Jean-Maurice Mallet

Jean-Frédéric Colombel

Reynald Chevalier

Pierre Sinay

Jacques Esnault

Pierre Desreumaux

Nadine Francois

Yann Guerardel

Marc Charles Victor Tabouret

Chantal Fradin

Adeline Sivignon

Guillaume Stoltz

Roland Gallo

Arlette Darfeuille - Michaud

Fradin Chantal

Sébastien Damiens

The present invention concerns an in vitro method for diagnosing invasive candidiasis (IC) in a subject which comprises detecting the presence of aglycan and detecting the presence of antibody directed against a protein selected from the group consisting of fructose bisphosphate aldolase (Fba1), enolase 1 (Eno1), heat shock protein 90 (Hsp90), hyphal wall protein (Hwp1), and mannoprotein 65 (Mp65) in a blood, plasma or serum sample of the subject. The invention also relates to a method of determining a suitable treatment regimen for a patient and to a kit for implanting the methods described herein.

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A method for the in vitro diagnosis of an invasive fungal infection by MALDI-TOF mass spectrometry. The method involves, providing a liquid biological sample from a mammal, said biological sample containing, in particular, proteins and/or lipids and/or salts and/or polysaccharides and/or oligosaccharides and/or monosaccharides capable of forming complexes with said proteins and/or lipids and/or salts; treating said sample with biological liquid so as to extract said polysaccharides and/or oligosaccharides and/or monosaccharides; determining, by MALDI-TOF mass spectrometry, whether or not there is present among said extracted polysaccharides, oligosaccharides and/or monosaccharides, at least one given compound of interest coming from said fungal microorganism and chosen from polysaccharides, oligosaccharides and monosaccharides; and deducing, if said given compound of interest is present in said sample, that said mammal is suffering from an invasive fungal infection.

In vitro diagnostic method for an invasive fungal infection using MALDI-TOFF mass spectrometry

The invention relates to novel yeast strains, to the yeasts resulting from these strains, to a composition containing at least oneyeast and/or derivatives of a yeast having a particular interest as a food additive and/or probiotic and/or functional food and/or neutraceutic and/or functional ingredient and/or cosmeceutical and/or pharmaceutical active agent. The invention also relates to the use of the same in human and/or animal nutrition, or for the treatment or prevention of inflammatory diseases.

Probiotic yeast compositions and methods for inflammatory diseases

A pharmaceutical composition including a therapeutically effective amount of at least one oligomannoside produced by chemical synthesis which is homologous to a wall oligomannoside of an infectious organism or pathogen, or a derivative thereof, and a pharmaceutically acceptable vehicle.

Synthetic oligomannosides, preparation and uses thereof

Growing community of inventors

Templeuve, France

Daniel Poulain