Northwestern University

King Abdulaziz City for Science and Technology

Uchicago Argonne, LLC

Daniel Patrick Ferris

James Fraser Stoddart

Karl A Hujsak

Karel J Hartlieb

James M Holcroft

Aleksandrs Prokofjevs

Dravid P Vinayak

Magdalena Owczarek

Daniel Seungbum Hong

Provided herein are substituted haloimidazole crystals, the substituted haloimidazole crystal comprising a substituted haloimidazole compound wherein the substituents are selected from the group consisting of hydrogen, an alkyl, and a halogen. The substituted haloimidazole crystals may further comprise second substituted haloimidazole. The substituted haloimidazole crystals may be piezoelectric, ferroelectric, flexible, or any combination thereof. Also provided herein are methods for preparing substituted haloimidazole crystals.

Flexible piezoelectric and ferroelectric haloimidazole crystals

Pharmaceutical complexes composed of drug molecules entrapped in cyclodextrin-based MOFs (CD-MOFs) are provided. Pharmaceutical tablets incorporating crystals of the pharmaceutical complexes for oral administration to a patient are also provided. In addition, methods of making the pharmaceutical complexes using anion-exchange reactions and methods of making the pharmaceutical complexes based on the co-crystallization of the drug molecules with cyclodextrin are provided. The pharmaceutical complexes include a CD-MOF and deprotonated drug anions associated with alkali metal cations in the CD-MOF superstructure.

Uptake of pharmaceuticals within cyclodextrin-based porous materials

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Evanston, IL, United States of America

Daniel Patrick Ferris