Centre National De La Recherche Scientifique

Institut National De La Sante Et De La Recherche Medicale

Cis Bio International

Daniel Parry

Jean-Claude Madelmont

Marie-France Moreau

Denise Godeneche

Jean-Louis Imbach

Joel Oiry

Josette Michelot

Pierre Lebarre

Gaston Meyniel

Gustin Meyniel

Annie J Veyre

##STR1## The invention concerns agents for diagnosing and treating malignant melanomas, of general formula (I), in which X denotes a hydrogen or halogen atom, Y denotes a Z--CONH--, Z--O--, Z--S(O)--.sub.n1 group, n.sub.1 being equal to 0,1,2 or 3, a Z--SO.sub.2 --NH-- Z--NHCO-- group, Z being a bond, a --CH.sub.2 -- or --CH(C.sub.6 H.sub.5)-- group, n is an integer between 2 and 4, and R.sub.1 and R.sub.2 each denote a hydrogen atom, a C.sub.1 to C.sub.6 alkyl group or a C.sub.6 to C.sub.12 aryl or aralkyl group, these compounds possibly being labelled by radioisotopes chosen from .sup.123 I, .sup.123 I, .sup.123 I, .sup.75 Br, .sup.77 Br, .sup.18 F, or .sup.11 C or by stable isotopes chosen from .sup.13 C and .sup.19 F, as well as their addition salts with pharmaceutically acceptable acids. The invention also concerns the use of these compounds to manufacture an agent for diagnosing and/or treating malignant melanomas.

Agents for diagnosing and treating melanomas, aromatic halogenated

Compounds having the general formula (I), ##STR1## wherein X and Y represent individually H or --NO, at least one of them being a group-NO, n is 0, 1 or 2, R represents hydrogen, an aliphatic, cycloaliphatic, cycloaliphatic-alkyl, aryl or aralkyl radical, or a group of formula, ##STR2## wherein R.sub.1 is a lower alkyl radical or an aryl, all these radicals being optionally substituted. The present invention also relates to the compounds hereabove defined in the form of mixtures of their position isomers. Furthermore, the present invention discloses processes for preparing such compounds, as well as compositions, useful particularly in anticancerous chemotherapy, containing at least one of said compounds as an active principle.

Nitrosoureas compounds preparation thereof and utilization thereof in

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Beaumont, France

Daniel Parry