Midatech Pharma (Wales) Limited

Q Chip Limited

Midatech Limited

Other

Midatech Pharma Limited

Daniel Palmer

Phillip Williams

Owen Lesley Shadick

Tom Coulter

Stephen Damment

Alessandro Pace

Robert Huw Davis

Paul Seaman

Rhian Groves

Victoria Cavalier-Hirth

Richard Calder

Stuart James Bartley

Brynmor Alexander John

Victoria Louise Workman

The present invention provides a method for producing a cyclodextrin-panobinostat adduct, comprising: a) providing a first aqueous solution comprising a buffering agent, the solution having a pH in the range 2.0 to 4.0; b) dissolving panobinostat in said first aqueous solution to provide a second aqueous solution; and c) mixing said second aqueous solution comprising panobinostat with a third aqueous solution comprising a cyclodextrin to form a fourth aqueous solution comprising a cyclodextrin-panobinostat adduct. Also provided is an artificial cerebrospinal fluid (CSF) solution comprising the cyclodextrin-panobinostat adduct and medical uses of the cyclodextrin-panobinostat adduct, including in the treatment of brain tumours.

Cyclodextrin-panobinostat adduct

The present invention provides a process for producing nanoparticles, comprising: providing a first liquid comprising a metal salt and at least one species of ligand having a functional group capable of binding to a metal surface, providing a second liquid comprising a reducing agent; providing at least one liquid droplet generator operable to generate liquid droplets, causing the at least one liquid droplet generator to form liquid droplets of the first liquid, passing the liquid droplets through a gas to contact the second liquid so as to cause the metal salt and the at least one species of ligand to come into contact with the reducing agent, thereby causing self-assembly of nanoparticles, said nanoparticles having a core of said metal and a corona comprising a plurality of said ligands covalently bound to the core. Also provided are nanoparticles produced by the process of the invention and use of such nanoparticles in medicine.

Nanoparticle production

A method of making solid beads is disclosed, said method comprising: (i) providing a microfluidic device comprising a carrier fluid conduit and a functional fluid conduit which meet at a junction region; (ii) providing a laminar flow of a functional fluid comprising a solvent and a solute along the functional fluid conduit and providing a laminar flow of a carrier fluid along the carrier fluid conduit so as to form droplets of functional fluid in a flow of carrier fluid; (iii) cooling the segments of functional fluid in a conduit of the microfluidic device to form cooled (preferably frozen) droplets; and (iv) providing a liquid into intimate admixture with the cooled droplets so as to cause said solvent to exit said cooled droplets, thus forming solid beads. A microfluidic device for use in such a method is also disclosed.

Device and method for making solid beads

A device is provided for separating beads from a carrier fluid, the device comprising: a bead-receiving means for receiving beads dispersed in a carrier fluid, a fluid removal means operable to remove fluid from the bead-receiving means in a first fluid removal zone by the application of reduced pressure, and a bead collection means operable to remove beads from the bead-receiving means in a bead collection zone by the application of reduced pressure, the bead-receiving means being movable so that beads are movable from the first fluid removal zone to the bead collection zone.

Bead collection device and method

A method of forming solid beads, the method comprising: Providing a first liquid comprising a solute and a solvent Forming liquid droplets of the first liquid Contacting the liquid droplets with a second liquid so as to cause the solvent to exit the droplets, thus forming solid beads, the solute comprising a polymer, the concentration of polymer in the first liquid being at least 7% w/v., the solubility of the solvent in the second liquid being at least 5 g of solvent per 100 ml of second liquid.

Method for making solid beads

An apparatus for making solid beads is provided, the apparatus comprising at least one liquid droplet generator operable to generate droplets comprising a solute dissolved in a solvent, and at least one flow channel for carrying a second liquid, at least one liquid droplet generator and at least one flow channel being spaced relative to one another so that, in use, liquid droplets pass through a gas into a second liquid provided in said flow channel, the solvent being soluble in the second liquid so as to cause the solvent to exit the droplets, thus forming solid beads. A method of preparing solid beads is also provided.

Apparatus and method for making solid beads

The present invention provides a method of controlling a chemical process, the method comprising the steps of: (i) providing a laminar flow of a first fluid, the first fluid providing a first reagent or one or more precursor thereof), a laminar flow of a second fluid, the second fluid providing a second reagent (or one or more precursor thereof) and a laminar flow of barrier fluid; and (ii) causing the first and barrier fluids to contact one another so that the barrier fluid forms a barrier between the first reagent (or one or more precursor thereof) and the second reagent (or one or more precursor thereof) wherein step (ii) comprises forming segments of first fluid encased or sandwiched by barrier fluid, the segments being surrounded by the second fluid, and the barrier fluid is permeable to one or both of the first and second reagents. Devices for performing the method of the present invention are also provided.

Device and method for the control of chemical processes

The invention provides a device () for producing a spherical segmented flow of fluid, which device includes: a functional fluid conduit () arranged to contain a functional fluid (); at least two carrier fluid conduits (), each carrier fluid conduit arranged to carry a carrier fluid (), the functional fluid conduit merging with the carrier fluid conduits at a junction () to form an encased flow conduit () thereby permitting functional fluid to be sandwiched (or encased) by the carrier fluid to form an encased flow, the encased flow conduit having a discontinuity () therein such that the encased flow forms into a flow of alternate segmented spheres after the discontinuity, wherein the device is provided with a segmented flow conduit () downstream of the encased flow conduit, the encased segmented flow conduit being provided with an enlargement () in cross-section.

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Cardiff, United Kingdom

Daniel Palmer