Waters Technologies Corporation

Other

Daniel P Walsh

Kevin Daniel Wyndham

Matthew A Lauber

Pamela Carmen Iraneta

Darryl W Brousmiche

Raymond P Fisk

Thomas H Walter

Nicole L Lawrence

Xin Zhang

John E O'Gara

Jonathan L Belanger

Jacob Nathan Fairchild

Mathew H DeLano

Stephen J Shiner

Julia Ding

MingCheng Xu

Yeliz Tunc Sarisozen

Andrew Wyatt Schmudlach

Andrew Bates-Harrison

Michael G Morse

The present disclosure pertains to composite particles with polymer-based cores, which eliminate the high pH failure mechanism of silica-based core-shell silica particles. In various embodiments, a non-porous polymer core is surface modified. In various embodiments, a non-porous hybrid organic-inorganic material is in contact with the modified surface of the core, and a porous inorganic material is in contact with the non-porous hybrid organic-inorganic material. The present disclosure pertains to chromatographic separation devices that comprise such composite particles.

Composite particles with non-porous hybrid organic-inorganic material

The present disclosure is directed to a coating process for chromatographic surfaces. Embodiments of the present disclosure feature a two-step, vapor-liquid phase organosilane deposition method for creating a hydrophilic, non-ionic surface in a chromatographic system.

Device including a hydrophilic, non-ionic coating for size exclusion chromatography

The present invention provides methods for performing supercritical fluid chromatography comprising loading a sample to be separated by supercritical fluid chromatography onto a stationary phase comprising a spherical, monodisperse, core-shell particulate material comprising a nonporous core and one or more layers of a porous shell material surrounding the core, wherein the particles are sized less than 2 microns; and performing supercritical fluid chromatography to separate the sample.

Chromatographic columns and separation devices comprising a superficially porous material; and use thereof for supercritical fluid chromatography and other chromatography

Provided herein are stationary phase compositions comprising a chromatographic surface of porous or non-porous core material comprising a surface modifier for use in chromatographic separations.

Chromatographic compositions

Methods, kits and devices for separating phospholipids and proteins from small molecules in biochemical samples can feature an apparatus having a wetting barrier, at least one frit and a separation media. For example, an apparatus can include at least one wall defining a chamber having an exit and an entrance; a wetting barrier disposed between the exit and entrance, so as to define a separation media space located between the wetting barrier and the exit and a sample receiving area located between the wetting barrier and the entrance; and a separation media disposed adjacent to the wetting barrier and having a specific affinity for phospholipids.

Methods, compositions, devices, and kits, for performing phospholipid separation

Novel materials for chromatographic separations, processes for their preparation, and separation devices containing the chromatographic materials. In particular, hybrid inorganic/organic monolith materials comprising a polymerized scaffolding nanocomposite (PSN), wherein the nanocomposite contains a scaffolding functionality capable of chemically interacting with a surface of a second material are described. The hybrid inorganic/organic materials have enhanced wall adhesion and increased resistance to shrinkage as compared to prior art monolith materials. The improved adhesion of the monoliths enable the preparation of capillary columns with an internal diameter (I.D.) &#x2265;50 &#x3bc;m.

Nanocomposites and their application as monolith columns

Methods, kits and devices for separating phospholipids and proteins from small molecules in biochemical samples can feature an apparatus having a wetting barrier, at least one fit and a separation media. For example, an apparatus can include at least one wall defining a chamber having an exit and an entrance; a wetting barrier disposed between the exit and entrance, so as to define a separation media space located between the wetting barrier and the exit and a sample receiving area located between the wetting barrier and the entrance; and a separation media disposed adjacent to the wetting barrier and having a specific affinity for phospholipids. The wetting barrier is adapted to (i) retain the liquid sample and a protein precipitating agent in the sample receiving area under a first force, thereby facilitating the formation of a protein precipitate and a processed sample, and (ii) flow the processed sample through the wetting barrier and separation media under a second force, wherein the second force is greater than the first force, thereby retaining the protein precipitate in the sample receiving area, retaining phospholipids in the separation media, and eluting small molecules.

Methods, compositions, devices, and kits for performing phospholipid separation

&ldquo;L&rdquo;-shaped brackets for connecting floor joists of houses to a structural band board and deck ledger board so that the deck ledger board will be supported by the weight-bearing floor joists of the houses. The brackets are &ldquo;L&rdquo;-shaped, having one short leg, one long leg, and at least one triangular brace connecting the legs. Each leg contains a plurality of holes for the passage of through bolts. The short legs abut the band board and the through bolts pass through the short legs of the brackets, the band board, and the ledger board. The long legs abut the weight-bearing joists and the through bolts pass through the long leg of one of the backet, one of the weight-bearing joists, and the long leg of one of the brackets on the opposing side of the weight-bearing joist.

Growing community of inventors

Danvers, MA, United States of America

Daniel P Walsh