Ortho-Clinical Diagnostics, Inc

Eastman-Kodak Company

Johnson & Johnson Clinical Diagnostics, Inc.

Daniel P Salotto

Zhong Ding

Edward R Scalice

David Angelo Tomasso

Raymond Francis Jakubowicz

Kory Adam Gunnerson

William Franklin Gottermeier

James Ellis Robinson

Andrew M Kirsch

Aaron Michael Swick

David A Tomasso

Kory A Gunnerson

Philip C Hosimer

Timothy C Warren

James D Kanaley

Raymond F Jakubowicz

John A Quenin

Carl Frederick Leidig

David Allen Heavner

Angelo M LaBarbera

Philip C Hosmier

Raymond S Burbott

Donald E Larson

A lateral-flow assay device includes a substrate having a sample addition zone and a wash addition zone downstream thereof along a fluid flow path through which a sample flows. The fluid flow path is configured to receive a wash fluid in the wash addition zone. A hydrophilic surface is arranged in the wash addition zone. Flow constriction(s) are spaced apart from the fluid flow path and arranged to define, with the hydrophilic surface, a reservoir configured to retain the wash fluid by formation of a meniscus between the hydrophilic surface and the flow constriction(s). The fluid flow path draws the wash fluid from the reservoir by capillary pressure. Apparatus for analyzing a fluidic sample and methods of displacing a fluidic sample in a fluid flow path of an assay device are also described.

Lateral-flow assay device having flow constrictions

Disclosed is an assay device which comprises a liquid sample addition zone, a reagent zone, a detection zone, and a wicking zone, all defining a fluid flow path. The device further comprises a reagent addition zone along and in fluid communication with the fluid flow path downstream of the sample addition zone and upstream of the detection zone. An interrupting wash is added at this reagent addition zone in accordance with the method of the subject invention to control sample volume. The interrupting wash fluid is added at a predetermined fill volume on the chip device and also serves to wash the detection channel and fill the remaining chip volume.

Assay device having controllable sample size

A sample collection device for a fluid includes: a substantially disk-shaped body having a periphery; a capillary channel extending through the body and bounded by the periphery, having a first end and a second end, wherein the first end is adapted to draw the fluid into the channel by capillary action; a sample collection well located in the vicinity of the second end and in fluid communication with the capillary channel; and an axis of rotation extending through the center of the disk and which is substantially perpendicular to the major surface of the disk-shaped body. In a preferred embodiment, the sample collection device is adapted to rotate about the axis of rotation within a cartridge having a housing comprising an air vent in fluid communication with the capillary channel when the disk is rotated in a first position.

Rotatable disk-shaped fluid sample collection device

A lateral flow assay device includes a substrate having a top surface, as well as a sample receiving area disposed upon the top surface. At least one fluid flow path extends along the substrate from the sample receiving area, wherein the sample receiving area can be placed in contact with a peripheral reservoir formed at a sample addition area to draw sample therefrom in a controlled manner. The device can further include a reagent area that is designed to promote uniform dissolution of a deposited detection material by a sample moved through the device along the fluid flow path as well, as a flow channel configure to promote mixing of sample and reagent and an absorbing or wicking zone configured to affect various flow characteristics.

Lateral flow assay device

A sample collection device for a fluid sample includes: a body including a capillary channel having a first end and a second end, wherein the first end is adapted to draw the fluid into the channel by capillary action; an air vent located in the vicinity of the second end and in fluid communication with the capillary channel; a barrier positioned within the capillary channel to prevent flow of the fluid by capillary action thereacross; and features on opposing sides of the body to form an axis of rotation, which is substantially perpendicular to the overall direction of the capillary channel from the first end to the second end. In a preferred embodiment, the sample collection device is adapted to rotate about the axis of rotation within a cartridge having a sample manipulation device to bring the first end into position with the sample manipulation device.

Rotatable fluid sample collection device

Processor for nucleic acid detection

A high efficiency optical mixer includes a source of focused radiant energy. The focused radiant energy is concentrated by a parabolic concentrator onto an exit port. A diffuse reflector, which can be planar or arcuate, is maintained in contact with the output port thereby minimizing optical losses and diffusely reflecting light from the concentrator. The reflected light can be transmitted, by fiber optics, to an optical system. A method is providing for concentrating focused radiant energy onto a selected area and diffusely reflecting same from that area.

Optical mixer

Growing community of inventors

Rochester, NY, United States of America

Daniel P Salotto