Eisai Company, Limited

Eisai R&d Management Co., Ltd.

Daniel P Rossignol

William J Christ

Seiichi Kobayashi

Tsutomu Kawata

Lynn D Hawkins

Osamu Asano

Sally T Ishizaka

Michael D Lewis

Scott Fields

Ronald G Thurman

William D Kerns

Mary Vermeulen

Jeffrey Rose

Pamela McGuiness

Pamela McGuinness

Clifford DiLea

Anneliese Nault

Melvyn Lynn

Scott Z Fields

Michael Lewis

The invention relates to immunotherapeutic compounds and to methods for stimulating an immune response in a subject individual at risk for developing cancer, diagnosed with a cancer, in treatment for cancer, or in post-therapy recovery from cancer or the compounds of the invention can be administered as a prophylactic to a subject individual to prevent or delay the development of cancer.

Compositions and methods for cancer immunotherapy

Novel substituted liposaccharides useful as in the prophylactic and affirmative treatment of endotoxemia including sepsis, septicemia and various forms of septic shock and methods of using these agents are provided. Also provided are methods of preparing these agents and intermediates useful therein.

Substituted liposaccharides useful in the treatment and prevention of endotoxemia

The invention provides methods for preventing and treating disease involving the use of an anti-endotoxin drug.

Use of an anti-endotoxin drug in the prevention and treatment of disease

The invention provides methods of preventing and treating pulmonary bacterial infection or symptomatic pulmonary exposure to endotoxin and related conditions in a patient by administering to the patient antiendotoxin compounds by inhalation.

Prevention and treatment of pulmonary bacterial infection or symptomatic pulmonary exposure to endotoxin by inhalation of antiendotoxin drugs

The present invention is directed to novel compounds that function as immunological adjuvants when co-administered with antigens such as vaccines for bacterial and viral diseases, to novel adjuvant formulations which include at least one of the adjuvant compounds of the invention, to novel immunostimulatory compositions which comprise an antigen and at least one of the adjuvant compounds of the invention, and to methods for the immunization of an animal by co-administration of a compound of the invention with an antigen against which the animal is to be immunized.

Immunological adjuvant compounds, compositions, and methods of use thereof

A method for the inhibition and amelioration of alcholic liver disease in a mammal in need of such treatment by administering novel analogs of Lipid A which act as endotoxin antagonists. These antagonists compounds are found to inhibit the swift increase in alcohol metabolism which typically accompanies ingestion of alcohol and which may lead to the pathophysiological abnormalities associated with alcoholic liver disease.

Method for treating alcoholic liver disease

Substituted liposaccharides useful in the treatment and prevention of

Disclosed are lipid A analogs useful for the treatment of septic shock and LPS-mediated activation of viral infection.

Anti-endotoxin compounds

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Mahwah, NJ, United States of America

Daniel P Rossignol