Roche Molecular Systems, Inc.

Roche Diagnostics Operations, Inc.

Roche Diagnostics Gmbh

F. Hoffmann-la Roche Ag

Daniel Ott

Joerg Burmester

Philipp Kull

Markus Thiel

Hans-Rudolf Bachmann

Mirko Klingauf

Ronald Egli

Jerome Wiss

Jörg Burmester

An in-vitro diagnostic device including a pipetting unit and a pipetting method, which allow for a more reproducible and more precise pipetting of liquids, when piercing through a lid of a closed liquid container is required. The pipetting unit is controlled to repeat penetration of the lid of the closed liquid container if the pressure difference between the interior of the liquid container and the surrounding is outside an allowable predefined pressure range.

Pipetting unit and pipetting method for closed liquid containers

A method of gravimetric volume determination is described in which a load cell can be calibrated either outside of an analytic analyzer for gravimetric calibration of the analyzer, or in a fully automated manner inside the analyzer.

Method for gravimetric volume determination

A device for the gravimetric volume determination of liquid volumes. The device comprises a housing () having the shape and dimensions of a standard rack used in a clinical diagnostic analyzer system for holding sample or reagent containers, and the following components contained in housing (): a load cell () for gravimetric volume determination, a weighing container () for receiving a liquid to be weighed with said load cell (), a windbreak () which shields said weighing container () from air flow, an evaporation trap () which prevents evaporation of liquid loaded into said weighing container (), a temperature sensor (), an air-pressure sensor () and a humidity sensor () for sensing temperature, air pressure and humidity respectively at predetermined points within said housing (), and an electronic processing unit for processing electrical output signals delivered by said load cell () and by said sensors ().

Device and method for the gravimetric determination of liquid volumes and analyzer system comprising such a device

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Baar, Switzerland

Daniel Ott