Brookhaven Science Associates, Lcc

Assoicated Universties, Inc.

Nanoprobes, Inc.

Microbeam Therapy, Llc.

The United States of America As Represented by the United States

Other

University of Connecticut

Microbeam Thearpy, Llc.

Elex Analytical Technologies Corp.

Daniel N Slatkin

Michiko Miura

James F Hainfeld

Fred H Geisler

F Avraham Dilmanian

John A Shelnutt

Samuel Packer

Lucian Wielopolski

Ralph G Fairchild

Jeffrey A Coderre

Henry M Smilowitz

Lois Ann Polatnick

Per O Spanne

John F Rosen

Peggy L Micca

Various embodiments relate to a microbeam radiation therapy (microbeam radiosurgery) system, including: a radiation beam source; a collimator with slits, wherein the collimator only passes a radiation beam from the radiation beam source through the slits; a filtering and limiting system; a source shutoff controller connected to the radiation beam source; and a detector configured to detect events requiring the shutdown of the radiation beam source.

Safety methods and apparatus for low dose-rate radiation for medical and veterinary therapies

Various embodiments relate to a method of performing microbeam radiation therapy (microbeam radiosurgery) for a subject, including: producing a high-energy radiation beam; shaping, attenuating, strengthening, hardening and/or otherwise appropriately modifying the high-energy radiation beam using a low-Z, high-Z, or variable-Z filter; passing the beam before or after it has been so modified through a collimator to produce high-dose regions alternating with low-dose regions; and irradiating the subject with the collimated beam so modified.

Low dose-rate radiation for medical and veterinary therapies with three dimensionally shaped profiles

Various embodiments relate to a method of performing microbeam radiation therapy on a subject, including: producing a high-energy radiation beam in a first direction; producing planar microbeams using the high-energy radiation beam in the first direction, wherein the microbeams have a width, wherein the planar microbeams produce scattered electrons; and applying a magnetic field in a direction lying in a plane substantially parallel to the planar microbeams, wherein the strength of the magnetic field corresponds to the width of the microbeam.

Magnetic confinement for microbeam radiation damage area

Various embodiments relate to a method of performing microbeam radiation therapy on a subject, including: affixing a collimator to the subject at a first location; producing a first high energy radiation fan beam, wherein the width of the first fan beam in a first direction is greater than the width of the first fan beam in a second direction; and moving the subject in the second direction so that the first fan beam irradiates the subject through the collimator to produce first high dose regions alternating with first low dose regions.

Low dose-rate radiation for medical and veterinary therapies

The present invention provides methods of using metal nanoparticles 0.5 to 400 nm in diameter to enhance the dose and effectiveness of x-rays or of other kinds of radiation in therapeutic regimes of ablating a target tissue, such as tumor. The metal nanoparticles can be administered intravenously, intra-arterially, or locally to achieve specific loading in and around the target tissue. The metal nanoparticles can also be linked to chemical and/or biochemical moieties which bind specifically to the target tissue. The enhanced radiation methods can also be applied to ablate unwanted tissues or cells ex vivo.

Methods of enhancing radiation effects with metal nanoparticles

The present invention provides methods of using metal nanoparticles 0.5 to 400 nm in diameter to enhance the dose and effectiveness of x-rays or of other kinds of radiation in therapeutic regimes of ablating a target tissue such as tumor. The metal nanoparticles can be administered intravenously, intra-arterially, or locally to achieve specific loading in and around the target tissue. The metal nanoparticles can also be linked to chemical and/or biochemical moieties which bind specifically to the target tissue. The enhanced radiation methods can also be applied to ablate unwanted tissues or cells ex vivo.

The present invention covers halogenated derivatives of boronated phorphyrins containing multiple carborane cages having the formulawhich selectively accumulate in neoplastic tissue within the irradiation volume and thus can be used in cancer therapies including, but not limited to, boron neutron-capture therapy and photodynamic therapy. The present invention also covers methods for using these halogenated derivatives of boronated porphyrins in tumor imaging and cancer treatment.

Use of novel metalloporphyrins as imageable tumor-targeting agents for radiation therapy

Metal nanoparticles are described that are useful for enhancing the contrast of x-rays or other radiation sources. A method is disclosed whereby the agents are administered intravenously or intra-arterially to detect coronary senses and other vascular features. It is also disclosed how directing moieties attached to the metal particles are used to detect specific targets.

Media and methods for enhanced medical imaging

Metalloporphyrins and their uses as radiosensitizers for radiation therapy

Metalloporphyrins and their uses as imageable tumor-targeting agents for radiation therapy

A method of optimizing malignancy therapy includes surgical removal or reduction of the body burden of malignant cells and retention of some of those cells for subsequent use in immunotherapy. Boron neutron-capture therapy is employed at a radiation dosage below the threshold for normal tissue necrosis to provide preservation of normal tissue structure. Normal tissue tolerable limits are in the range of 10-13 GY-Eq. The removed tumor cells are altered by radiation or genetically to render them incapable of unlimited clonogenic propagation and then reinjected using multiple sequenced injections.

Method for improvement of radiation therapy of malignant tumors

The present invention covers boronated porphyrins containing multiple carborane cages which selectively accumulate in neoplastic tissue within the irradiation volume and thus can be used in cancer therapies such as boron neutron capture therapy and photodynamic therapy.

Boronated porhyrins and methods for their use

A method for performing boron neutron capture therapy for the treatment of tumors is disclosed. The method includes administering to a patient an iodinated sulfidohydroborane, a boron-10-containing compound. The site of the tumor is localized. by visualizing the increased concentration of the iodine labelled compound at the tumor. The targeted tumor is then irradiated with a beam of neutrons having an energy distribution effective for neutron capture. Destruction of the tumor occurs due to high LET particle irradiation of the tissue secondary to the incident neutrons being captured by the boron-10 nuclei. Iodinated sulfidohydroboranes are disclosed which are especially suitable for the method of the invention. In a preferred embodiment, a compound having the formula Na.sub.4 B.sub.12 I.sub.11 SSB.sub.12 I.sub.11, or another pharmaceutically acceptable salt of the compound, may be administered to a cancer patient for boron neutron capture therapy.

Growing community of inventors

Essex, CT, United States of America

Daniel N Slatkin